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1. (WO2017110705) AGENT FOR ENHANCING SYNAPSE FORMATION AND THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/110705 International Application No.: PCT/JP2016/087700
Publication Date: 29.06.2017 International Filing Date: 19.12.2016
IPC:
A61K 31/7088 (2006.01) ,A61K 35/76 (2015.01) ,A61K 35/761 (2015.01) ,A61K 48/00 (2006.01) ,A61P 21/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/14 (2006.01) ,A61P 25/16 (2006.01) ,A61P 25/28 (2006.01) ,A61P 43/00 (2006.01) ,C12N 15/113 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
76
Viruses
[IPC code unknown for A61K 35/761]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
国立研究開発法人国立精神・神経医療研究センター NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY [JP/JP]; 東京都小平市小川東町4丁目1番1号 1-1, Ogawahigashi-cho 4-chome, Kodaira-shi, Tokyo 1878551, JP
Inventors:
北條 浩彦 HOJO Hirohiko; JP
高橋 理貴 TAKAHASHI Masaki; JP
Agent:
平木 祐輔 HIRAKI Yusuke; JP
藤田 節 FUJITA Takashi; JP
漆山 誠一 URUSHIYAMA Seiichi; JP
Priority Data:
2015-24821921.12.2015JP
Title (EN) AGENT FOR ENHANCING SYNAPSE FORMATION AND THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE
(FR) AGENT POUR L'AMÉLIORATION DE FORMATION DE SYNAPSES ET AGENT THÉRAPEUTIQUE POUR MALADIE NEURODÉGÉNÉRATIVE
(JA) シナプス形成増強剤及び神経変性疾患治療剤
Abstract:
(EN) The present invention addresses the problem of developing a drug capable of regrowing synapses, which have been damaged and lost due to a neurodegenerative disease, to thereby provide a medicinal composition for preventing or treating a neurodegenerative disease on the basis of the effect of the aforesaid drug. Provided is a therapeutic agent for a neurodegenerative disease which comprises an agent for enhancing synapse formation, said agent comprising miR132 or miR212, as an active ingredient.
(FR) La présente invention vise à développer un médicament capable d'effectuer la repousse des synapses, qui ont été endommagées ou détruites suite à une maladie neurodégénérative, afin d'obtenir une composition médicinale pour la prévention ou le traitement d'une maladie neurodégénérative basée sur l'effet dudit médicament. À cet effet, l'invention concerne un agent thérapeutique pour une maladie neurodégénérative qui comporte un agent pour améliorer la formation des synapses, ledit agent comprenant miR132 et miR212en tant que principe actif.
(JA) 神経変性疾患により破壊され、消失したシナプスを再形成させる薬剤を開発し、その効果によって、神経変性疾患を予防又は治療する医薬組成物の提供を課題とする。 miR132又はmiR212からなるシナプス形成増強剤を有効成分とする神経変性疾患治療剤を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)