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1. (WO2017110669) POLYMER CONJUGATE OF SULFOXIDE DERIVATIVE-COORDINATED PLATINUM(II) COMPLEX
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/110669 International Application No.: PCT/JP2016/087521
Publication Date: 29.06.2017 International Filing Date: 16.12.2016
IPC:
C08G 69/48 (2006.01) ,A61K 31/282 (2006.01) ,A61K 31/555 (2006.01) ,A61K 47/50 (2017.01) ,A61P 35/00 (2006.01) ,C08G 65/334 (2006.01) ,C08G 69/08 (2006.01) ,C08G 81/00 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69
Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
48
Polymers modified by chemical after-treatment
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
555
containing heavy metals, e.g. hemin, hematin, melarsoprol
[IPC code unknown for A61K 47/50]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
65
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
02
from cyclic ethers by opening of the heterocyclic ring
32
Polymers modified by chemical after-treatment
329
with organic compounds
334
containing sulfur
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69
Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02
Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids
08
derived from amino carboxylic acids
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
81
Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
Applicants:
日本化薬株式会社 NIPPON KAYAKU KABUSHIKI KAISHA [JP/JP]; 東京都千代田区丸の内二丁目1番1号 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 1000005, JP
Inventors:
中村 雅陽 NAKAMURA Masaharu; JP
福田 剛 FUKUDA Tsuyoshi; JP
山川 健 YAMAKAWA Ken; JP
加藤 卓也 KATO Takuya; JP
Agent:
特許業務法人川口國際特許事務所 KAWAGUTI & PARTNERS; 東京都新宿区北新宿二丁目21番1号新宿フロントタワー20階 Shinjuku Front Tower 20F, 2-21-1 Kita-Shinjuku, Shinjuku-ku, Tokyo 1690074, JP
Priority Data:
2015-25025522.12.2015JP
Title (EN) POLYMER CONJUGATE OF SULFOXIDE DERIVATIVE-COORDINATED PLATINUM(II) COMPLEX
(FR) CONJUGUÉ POLYMÈRE À BASE D'UN COMPLEXE DE PLATINE (II) COORDONNÉ À UN DÉRIVÉ DE SULFOXYDE
(JA) スルホキシド誘導体配位白金(II)錯体の高分子結合体
Abstract:
(EN) [Problem] A DDS preparation of a platinum complex showing the high antitumor effect and reduced side effects required as a medicine, that is, a clinically useable DDS preparation of a platinum complex characterized by being conjugated to a polymer carrier different from conventional ones, is desired. [Solution] Provided is a polymer conjugate of a platinum(II) complex, in which the sulfoxide group of a sulfoxide derivative introduced into a side chain carboxy group in a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety is coordinated to the platinum.
(FR) Le problème selon l'invention est que l'on souhaite mettre au point un système d'administration d'un complexe de platine présentant le puissant effet antitumoral et les effets secondaires réduits requis d'un médicament, c'est-à-dire un système d'administration de médicament pouvant être utilisé en clinique pour un complexe de platine, caractérisé en ce qu'il est conjugué à un support polymère différent des supports classiques. La solution consiste en un conjugué polymère d'un complexe de platine (II), dans lequel le groupe sulfoxyde d'un dérivé de sulfoxyde introduit dans un groupe carboxy formant une chaîne latérale d'un copolymère séquencé comportant une fraction structurale correspondant au polyéthylèneglycol et une fraction acide polyaspartique ou une fraction acide polyglutamique est coordonné au platine.
(JA) 【課題】医薬として求められる高い抗腫瘍効果と副作用の低減を示す白金錯体のDDS製剤、即ち従来とは異なる高分子担体に結合されることを特徴とする、臨床で使用可能な白金錯体のDDS製剤が望まれている。 【解決手段】ポリエチレングリコール構造部分と、ポリアスパラギン酸部分またはポリグルタミン酸部分とを有するブロック共重合体における側鎖カルボキシ基に導入したスルホキシド誘導体の該スルホキシド基が白金に配位結合した白金(II)錯体の高分子結合体を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
AU2016374759CA3009130CN108473676KR1020180099734IN201817025107EP3395857
US20180369254