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1. (WO2017110425) THERAPEUTIC AGENT FOR LIVER DISEASE AND METHOD FOR TREATING LIVER DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/110425 International Application No.: PCT/JP2016/085917
Publication Date: 29.06.2017 International Filing Date: 02.12.2016
IPC:
A61K 35/35 (2015.01) ,A61K 35/28 (2015.01) ,A61K 38/00 (2006.01) ,A61P 1/16 (2006.01) ,C07K 14/475 (2006.01) ,C07K 14/54 (2006.01) ,C12N 5/077 (2010.01)
[IPC code unknown for A61K 35/35]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
Applicants:
ロート製薬株式会社 ROHTO PHARMACEUTICAL CO., LTD. [JP/JP]; 大阪府大阪市生野区巽西1丁目8番1号 1-8-1, Tatsumi-nishi, Ikuno-ku, Osaka-shi, Osaka 5448666, JP
国立研究開発法人国立がん研究センター NATIONAL CANCER CENTER [JP/JP]; 東京都中央区築地五丁目1番1号 1-1,Tsukiji 5-chome,Chuo-ku, Tokyo 1040045, JP
Inventors:
倉田 隼人 KURATA, Hayato; JP
落谷 孝広 OCHIYA, Takahiro; JP
Agent:
特許業務法人 津国 TSUKUNI & ASSOCIATES; 東京都千代田区麹町5-3-1 麹町ビジネスセンター Kojimachi Business Center, 5-3-1, Kojimachi, Chiyoda-ku, Tokyo 1020083, JP
山村 大介 YAMAMURA, Daisuke; JP
森田 慶子 MORITA, Yoshiko; JP
Priority Data:
2015-25036122.12.2015JP
Title (EN) THERAPEUTIC AGENT FOR LIVER DISEASE AND METHOD FOR TREATING LIVER DISEASE
(FR) AGENT THÉRAPEUTIQUE POUR MALADIE HÉPATIQUE ET PROCÉDÉ DE TRAITEMENT D'UNE MALADIE HÉPATIQUE
(JA) 肝疾患治療剤及び肝疾患を治療する方法
Abstract:
(EN) The purpose of the present invention is to provide a novel therapeutic agent for a liver disease. Provided is a therapeutic agent for liver disease that comprises microparticles derived from interstitial cells. The microparticles preferably have an average particle size of 1,000 nm or smaller. The therapeutic agent for a liver disease according to the present invention preferably comprises interstitial cells that contain the aforesaid microparticles or are capable of secreting the microparticles.
(FR) L'invention concerne un nouvel agent thérapeutique pour le traitement d'une maladie hépatique. L'invention concerne un agent thérapeutique destiné au traitement d'une maladie hépatique qui comprend des microparticules dérivées de cellules interstitielles. Les microparticules présentent de préférence une granulométrie moyenne inférieure ou égale à 1 000 nm. L'agent thérapeutique destiné au traitement d'une maladie hépatique, selon la présente invention, comprend de préférence des cellules interstitielles qui contiennent les microparticules susmentionnées ou étant apte à secréter les microparticules.
(JA) 本発明は、肝疾患の新規治療剤を提供することを目的とする。本発明は、間質細胞由来の微小粒子を含有する、肝疾患治療剤である。上記微小粒子の平均粒子径は、1,000nm以下であることが好ましい。また、本発明の肝疾患治療剤は、上記微小粒子を含有又は分泌する能力を有する間質細胞を含むことが好ましい。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)