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1. (WO2017108736) N-[3-(3-{4-[[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY]-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL} -UREIDO)-PHENYL]-METHANESULFONAMIDE DERIVATIVES AND THEIR USE AS P38 MAPK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/108736 International Application No.: PCT/EP2016/081836
Publication Date: 29.06.2017 International Filing Date: 20.12.2016
IPC:
C07D 471/04 (2006.01) ,A61K 31/437 (2006.01) ,A61P 11/00 (2006.01) ,A61P 11/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
Applicants:
CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A 43122 Parma, IT
Inventors:
CAPALDI, Carmelida; IT
ARMANI, Elisabetta; IT
JENNINGS, Andrew Stephen Robert; IT
HURLEY, Christopher; IT
Agent:
MINOJA, Fabrizio; IT
Priority Data:
15202346.123.12.2015EP
Title (EN) N-[3-(3-{4-[[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY]-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL} -UREIDO)-PHENYL]-METHANESULFONAMIDE DERIVATIVES AND THEIR USE AS P38 MAPK INHIBITORS
(FR) DÉRIVÉS DE N-[3-(3-{4-[[1,2,4] TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY] -1,2,3,4-TÉTRAHYDRO-NAPHTALÉN-1-YL}-URÉIDO)-PHÉNYL]-MÉTHANESULFONAMIDE ET LEUR UTILISATION COMME INHIBITEURS DE LA P38 MAPK
Abstract:
(EN) This invention relates to compounds of formula (I) wherein R1 is selected from the group consisting of (A), (B), (C), (D), (E) (F) pharmaceutically acceptable salts thereof, and to compositions that are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
(FR) La présente invention concerne des composés de formule (I) R1 étant sélectionné dans le groupe constitué de (A), (B), (C), (D), (E) (F), des sels pharmaceutiquement acceptables de ceux-ci, et des compositions qui sont des inhibiteurs de la p38 MAPK, utiles en tant qu'agents anti-inflammatoires dans le traitement, entre autres, de maladies des voies respiratoires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)