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1. (WO2017100377) MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM
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Pub. No.: WO/2017/100377 International Application No.: PCT/US2016/065465
Publication Date: 15.06.2017 International Filing Date: 07.12.2016
IPC:
G06F 19/22 (2011.01) ,G06F 19/28 (2011.01) ,C12N 15/10 (2006.01)
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
22
for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or SNP [Single-Nucleotide Polymorphism] discovery or sequence alignment
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
28
for programming tools or database systems, e.g. ontologies, heterogeneous data integration, data warehousing or computing architectures
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
Applicants:
ZYMERGEN INC. [US/US]; 5980 Horton Street, Suite 105 Emeryville, California 94608, US
Inventors:
SERBER, Zach; US
DEAN, Erik Jedediah; US
MANCHESTER, Shawn; US
GORA, Katherine; US
FLASHMAN, Michael; US
SHELLMAN, Erin; US
KIMBALL, Aaron; US
SZYJKA, Shawn; US
FREWEN, Barbara; US
TREYNOR, Thomas; US
BRUNO, Kenneth S.; US
Agent:
HOLLY, David C.; US
VITENHEIMER, Erich E.; US
TUSCAN, Michael S.; US
POMERANZ, Marcelo C.; US
Priority Data:
15/140,29627.04.2016US
62/264,23207.12.2015US
62/368,78629.07.2016US
Title (EN) MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM
(FR) AMÉLIORATION DE SOUCHES MICROBIENNES PAR UNE PLATEFORME D'INGÉNIERIE GÉNOMIQUE HTP
Abstract:
(EN) The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.
(FR) La présente invention concerne une plateforme d'ingénierie génomique microbienne HTP qui est entraînée par informatique et qui intègre la biologie moléculaire, l'automatisation et les protocoles d'apprentissage automatique perfectionnés. Cette plateforme d'intégration utilise une suite de séries d'outils moléculaires HTP pour créer des bibliothèques de conception génétiques HTP qui proviennent, entre autres, de connaissances scientifiques et de reconnaissance de formes itératives. La plateforme d'ingénierie génomique HTP selon l'invention est une souche microbienne hôte agnostique et peut donc être mise en œuvre sur les taxons. La plateforme selon l'invention peut par ailleurs être mise en œuvre pour moduler ou améliorer tout paramètre d'hôte microbien présentant un intérêt.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)