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1. (WO2017100377) MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM

Pub. No.:    WO/2017/100377    International Application No.:    PCT/US2016/065465
Publication Date: Fri Jun 16 01:59:59 CEST 2017 International Filing Date: Thu Dec 08 00:59:59 CET 2016
IPC: G06F 19/22
G06F 19/28
C12N 15/10
Applicants: ZYMERGEN INC.
Inventors: SERBER, Zach
DEAN, Erik Jedediah
MANCHESTER, Shawn
GORA, Katherine
FLASHMAN, Michael
SHELLMAN, Erin
KIMBALL, Aaron
SZYJKA, Shawn
FREWEN, Barbara
TREYNOR, Thomas
BRUNO, Kenneth S.
Title: MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM
Abstract:
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.