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1. (WO2017100376) PROMOTERS FROM CORYNEBACTERIUM GLUTAMICUM
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Pub. No.: WO/2017/100376 International Application No.: PCT/US2016/065464
Publication Date: 15.06.2017 International Filing Date: 07.12.2016
IPC:
C12N 15/77 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
77
for Corynebacterium; for Brevibacterium
Applicants:
ZYMERGEN INC. [US/US]; 6121 Hollis Street, #700 Emeryville, California 94608, US
Inventors:
SERBER, Zach; US
GORA, Katherine G.; US
MANCHESTER, Shawn P.; US
Agent:
LORENZ, Todd; US
DREGER, Ginger; US
DEVRY, Christopher; US
PELLETIER, Benjamin; US
MARSH, David R.; US
SHARIFAHMADIAN, Ali; US
RIEMENSCHNEIDER, Kristen; US
ALTMANN, Curtis; US
XU, Morgan; US
MCMULLEN, David C.; US
CHUBO, Bonnie; US
Priority Data:
62/264,23207.12.2015US
62/431,40907.12.2016US
Title (EN) PROMOTERS FROM CORYNEBACTERIUM GLUTAMICUM
(FR) PROMOTEURS DE CORYNEBACTERIUM GLUTAMICUM
Abstract:
(EN) Provided are native promoters comprising polynucleotides isolated from Corynebacterium glutamicum, and mutant promoters derived therefrom, which may be used to regulate, i.e., either increase or decrease, gene expression. Also provided are promoter ladders comprising a plurality of the promoters having incrementally increasing promoter activity. Also provided are host cells and recombinant vectors comprising the promoters, and methods of expressing genes of interest and producing biomolecules using the host cells.
(FR) La présente invention concerne des promoteurs natifs comprenant des polynucléotides isolés à partir de Corynebacterium glutamicum, ainsi que des promoteurs mutants dérivés de ceux-ci, qui peuvent être utilisés pour réguler, c'est-à-dire, augmenter ou réduire, l'expression génique. L'invention concerne également des échelles de promoteurs comprenant une pluralité des promoteurs présentant une activité de promoteur augmentant progressivement. L'invention concerne également des cellules hôtes et des vecteurs recombinés comprenant lesdits promoteurs, ainsi que des procédés d'expression de gènes d'intérêt et de production de biomolécules au moyen des cellules hôtes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)