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1. (WO2017099823) COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/099823 International Application No.: PCT/US2016/000129
Publication Date: 15.06.2017 International Filing Date: 10.12.2016
Chapter 2 Demand Filed: 10.10.2017
IPC:
A61K 9/127 (2006.01) ,A61K 9/133 (2006.01) ,C12N 15/88 (2006.01) ,A61K 31/7088 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
133
Unilamellar vesicles
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88
using micro-encapsulation, e.g. using liposome vesicle
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
Applicants:
MODERNATX, INC. [US/US]; 320 Bent Street Cambridge, MA 02141, US
Inventors:
BESIN, Gilles; US
HOGE, Stephen; US
SENN, Joseph; US
BENENATO, Kerry; US
SABNIS, Staci; US
Agent:
LOCKHART, Helen, C.; US
Priority Data:
62/265,97310.12.2015US
62/266,58112.12.2015US
62/311,38021.03.2016US
62/311,38621.03.2016US
62/311,38821.03.2016US
62/350,16514.06.2016US
62/350,17214.06.2016US
62/413,02726.10.2016US
62/413,05026.10.2016US
Title (EN) COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
(FR) COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
Abstract:
(EN) This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
(FR) Cette invention concerne des compositions à base de lipides, comprenant des compositions de nanoparticules lipidiques, et des procédés d'utilisation de ces compositions pour administrer in vivo des agents comprenant des acides nucléiques et des protéines. Ces compositions ne subissent par de clairance sanguine accélérée et présentent un meilleur profil de toxicité in vivo.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3007955AU2016366978EP3386484