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1. (WO2017099413) COMPOSITION COMPRISING ENZYME-TREATED ROSA MULTIFLORA FRUIT EXTRACT AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING TH2-MEDIATED IMMUNOLOGICAL DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/099413 International Application No.: PCT/KR2016/013971
Publication Date: 15.06.2017 International Filing Date: 30.11.2016
IPC:
A61K 36/73 (2006.01) ,A23L 33/105 (2016.01) ,A61K 8/97 (2017.01) ,A61Q 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
73
Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
[IPC code unknown for A23L 33/105]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
96
containing materials, or derivatives thereof, of undetermined constitution
97
of vegetable origin, e.g. plant extracts
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
Applicants:
한국식품연구원 KOREA FOOD RESEARCH INSTITUTE [KR/KR]; 경기도 성남시 분당구 안양판교로1201번길 62 62, Anyangpangyo-ro 1201beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13539, KR
Inventors:
손동화 SHON, Dong-Hwa; KR
신희순 SHIN, Hee Soon; KR
도정룡 DO, Jeong-Ryong; KR
이소영 LEE, So Young; KR
최대운 CHOI, Dae Woon; KR
정선영 JUNG, Sun Young; KR
시혜정 SEE, Hye-Jeong; KR
권다애 KWON, Da-Ae; KR
백수연 BACK, Su Yeon; KR
엄지은 EOM, Ji Eun; KR
Agent:
이명진 LEE, Myoung-Jin; KR
Priority Data:
10-2015-017458209.12.2015KR
10-2016-016017929.11.2016KR
Title (EN) COMPOSITION COMPRISING ENZYME-TREATED ROSA MULTIFLORA FRUIT EXTRACT AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING TH2-MEDIATED IMMUNOLOGICAL DISEASE
(FR) COMPOSITION COMPRENANT UN EXTRAIT DE FRUIT DE ROSA MULTIFLORA TRAITÉ PAR ENZYME EN TANT QUE SUBSTANCE ACTIVE POUR PRÉVENIR OU TRAITER UNE MALADIE IMMUNOLOGIQUE MÉDIÉE PAR TH2
(KO) 효소처리 영실 추출물을 유효성분으로 포함하는 TH2-매개 면역질환의 예방 또는 치료용 조성물
Abstract:
(EN) The present invention relates to a composition comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient for preventing or treating a Th2-mediated immune disease. The composition according to the present invention can maximize the anti-allergic effect of the Rosa multiflora fruit extract by comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient. Specifically, the present inventors verified that, as a result of treating splenocytes of OVA-immunized mice with an enzyme-treated Rosa multiflora fruit extract, the enzyme-treated Rosa multiflora fruit extract remarkably promoted IL-4 production inhibitory activity compared with an enzyme-non-treated Rosa multiflora fruit extract and the in vivo oral administration of the enzyme-treated Rosa multiflora fruit extract remarkably reduced the blood IgE content in the OVA-immunized mice. In addition, the composition according to the present invention has advantages of being biocompatible and having excellent stability due to the use of Rosa multiflora fruit as a natural material, and thus, the composition is expected to be favorably used in the development of a safe therapeutic agent, a health functional food, a cosmetic product, and the like for the prevention, improvement, or treatment of a Th2-mediated immune disease.
(FR) La présente invention concerne une composition comprenant un extrait de fruit de Rosa multiflora traité par enzyme en tant que substance active pour prévenir ou traiter une maladie immunitaire médiée par Th2. La composition selon la présente invention peut maximiser l'effet antiallergique de l'extrait de fruit de Rosa multiflora en incluant un extrait de fruit de Rosa multiflora traité par enzyme en tant que substance active. Spécifiquement, les présents inventeurs ont vérifié que, en conséquence du traitement de splénocytes de souris immunisées par OVA avec un extrait de fruit de Rosa multiflora traité par enzyme, l'extrait de fruit de Rosa multiflora traité par enzyme stimule de façon remarquable l'activité inhibitrice de production d'IL-4 par rapport à un extrait de fruit de Rosa multiflora non traité par enzyme et l'administration orale in vivo de l'extrait de fruit de Rosa multiflora traité par enzyme réduit de façon remarquable la teneur en IgE dans le sang chez les souris immunisées par OVA. De plus, la composition selon la présente invention présente les avantages d'être biocompatible et d'avoir une excellente stabilité grâce à l'utilisation du fruit de Rosa multiflora en tant que matériau naturel, et donc, la composition devrait pouvoir être favorablement utilisée dans le développement d'un agent thérapeutique sûr, d'un aliment fonctionnel de santé, d'un produit cosmétique, et similaire pour la prévention, l'amélioration ou le traitement d'une maladie immunitaire médiée par Th2.
(KO) 본 발명은 효소가 처리된 영실 추출물을 유효성분으로 포함하는, Th2-매개 면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 조성물은 효소처리 영실 추출물을 유효성분으로 포함함으로써, 영실 추출물의 항알레르기 효능을 극대화할 수 있다. 구체적으로, 본 발명자들은 OVA로 면역시킨 마우스의 비장세포에 효소처리 영실 추출물을 처리한 결과 효소를 처리하지 않은 영실 추출물에 비하여 IL-4 생성 억제활성이 현저하게 증진되며, in vivo에서 효소처리 영실 추출물의 경구 투여에 의해 OVA로 면역시킨 마우스의 혈중 IgE 함량이 현저히 감소하는 것을 확인하였다. 또한, 천연물인 영실을 이용하므로 생체 친화적이고 안정성이 우수한 장점이 있으므로, 본 발명에 따른 조성물은 Th2-매개 면역질환의 예방, 개선, 또는 치료를 위한 안전한 치료제, 건강기능성 식품, 및 화장품 등의 개발에 유용하게 이용될 수 있을 것으로 기대된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)