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1. (WO2017099238) PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/099238 International Application No.: PCT/JP2016/086794
Publication Date: 15.06.2017 International Filing Date: 09.12.2016
IPC:
A61K 31/7088 (2006.01) ,A61K 9/127 (2006.01) ,A61K 31/7105 (2006.01) ,A61K 31/711 (2006.01) ,A61K 31/713 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
711
Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
東レ株式会社 TORAY INDUSTRIES, INC. [JP/JP]; 東京都中央区日本橋室町2丁目1番1号 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666, JP
Inventors:
宮野 敦子 MIYANO Atsuko; JP
須藤 裕子 SUDO Hiroko; JP
高山 愛子 TAKAYAMA Aiko; JP
荒井 大河 ARAI Taiga; JP
Agent:
平木 祐輔 HIRAKI Yusuke; JP
藤田 節 FUJITA Takashi; JP
小瀬村 暁子 KOSEMURA Akiko; JP
Priority Data:
2015-24095110.12.2015JP
Title (EN) PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
(FR) COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT ET/OU LA PRÉVENTION DU CANCER
(JA) 癌の治療及び/又は予防用医薬組成物
Abstract:
(EN) The present invention provides a new pharmaceutical composition for treating and/or preventing cancer having as an active ingredient a polynucleotide derived from various miRNAs associated with cancer, a combination pharmaceutical of this pharmaceutical composition and another antitumor agent, and a method for treating a subject having cancer or preventing cancer by using this pharmaceutical composition or combination pharmaceutical. The present invention pertains to a pharmaceutical composition for treating and/or preventing cancer including as an active ingredient a polynucleotide including a base sequence represented by SEQ ID NO: 1 or 2 (however, when at least part of the polynucleotide is DNA, uracil in the region corresponding to the DNA in the base sequence is replaced with thymine).
(FR) La présente invention concerne une nouvelle composition pharmaceutique pour le traitement et/ou la prévention du cancer comportant comme principe actif un polynucléotide dérivé de divers miARN associés au cancer, une association pharmaceutique de cette composition pharmaceutique et d'un autre agent antitumoral, et une méthode de traitement de patients atteints de cancer ou de prévention du cancer au moyen de cette composition pharmaceutique ou association pharmaceutique. La présente invention concerne une composition pharmaceutique pour le traitement et/ou la prévention du cancer comprenant comme principe actif un polynucléotide comprenant une séquence de base représentée par SEQ ID NO : 1 ou 2 (cependant, lorsqu'au moins une partie du polynucléotide est de l'ADN, l'uracile dans la région correspondant à l'ADN dans la séquence de base est remplacée par la thymine).
(JA) 本発明は、癌と関連する様々なmiRNAを由来とするポリヌクレオチドを有効成分とする新たな癌の治療及び/又は予防用医薬組成物、この医薬組成物と別の抗腫瘍剤との組み合わせ医薬品、並びに、これらの医薬組成物又は組み合わせ医薬品を用いて癌をもつ被検体を治療又は予防する方法を提供する。本発明は、配列番号1又は2で表される塩基配列を含むポリヌクレオチドを有効成分として含む、癌の治療及び/又は予防用医薬組成物(但し前記ポリヌクレオチドの少なくとも一部がDNAである場合、前記塩基配列中のDNAに相当する領域のウラシルはチミンに読み替える)に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
JPWO2017099238EP3388067US20180362981