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1. (WO2017099222) INTERLEUKIN-18 ACTIVITY INHIBITOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/099222 International Application No.: PCT/JP2016/086731
Publication Date: 15.06.2017 International Filing Date: 09.12.2016
IPC:
A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 43/00 (2006.01) ,C07K 14/54 (2006.01) ,C12N 15/09 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
国立大学法人京都大学 KYOTO UNIVERSITY [JP/JP]; 京都府京都市左京区吉田本町36番地1 36-1, Yoshida-honmachi, Sakyo-ku, Kyoto-shi, Kyoto 6068501, JP
国立大学法人岐阜大学 GIFU UNIVERSITY [JP/JP]; 岐阜県岐阜市柳戸1番1 1-1, Yanagido, Gifu-shi, Gifu 5011193, JP (JP)
Inventors:
杤尾 豪人 TOCHIO, Hidehito; JP
堤 尚孝 TSUTSUMI, Naotaka; JP
横田 歩 YOKOTA, Ayumi; JP
大西 秀典 OHNISHI, Hidenori; JP
木村 豪 KIMURA, Takeshi; JP
加藤 善一郎 KATO, Zenichiro; JP
Agent:
鮫島 睦 SAMEJIMA, Mutsumi; JP
落合 康 OCHIAI, Ko; JP
Priority Data:
2015-24209111.12.2015JP
Title (EN) INTERLEUKIN-18 ACTIVITY INHIBITOR
(FR) INHIBITEUR DE L'ACTIVITÉ DE L'INTERLEUKINE-18
(JA) インターロイキン-18活性阻害剤
Abstract:
(EN) Provided is a novel prophylactic or therapeutic agent for various diseases caused by IL-18 activity, more specifically, a medicine that comprises a peptide selected from the group consisting of (a) to (c) or a salt thereof: (a) a peptide containing an amino acid sequence represented by SEQ ID NO:1; (b) a peptide containing an amino acid sequence having at least 60% identity to the amino acid sequence represented by SEQ ID NO:1 and having an effect of inhibiting IL-18 activity; and (c) a peptide having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion, substitution, insertion and/or addition of one or more amino acid residues and having an effect of inhibiting IL-18 activity.
(FR) La présente invention concerne un nouvel agent prophylactique ou thérapeutique pour diverses maladies en relation avec l'activité de l'IL-18, plus spécifiquement, un médicament qui comprend un peptide sélectionné au sein du groupe constitué par les composants (a) à (c) ou un sel de ces derniers : (a) un peptide comprenant une séquence d'acides aminés représentée par SEQ ID NO : 1 ; (b) un peptide comprenant une séquence d'acides aminés présentant au moins 60 % d'identité avec la séquence d'acides aminés représentée par SEQ ID NO : 1, et présentant un effet inhibiteur sur l'activité de l'IL-18 ; et (c) un peptide dont la séquence d'acides aminés est dérivée de la séquence d'acides aminés représentée par SEQ ID NO : 1 par délétion, substitution, insertion et/ou addition d'un ou de plusieurs résidus acide aminé, et présentant un effet inhibiteur sur l'activité de l'IL-18.
(JA) 本発明は、IL-18の活性に起因する様々な疾患の新たな予防または治療剤、より具体的には、下記(a)~(c)からなる群から選択されるペプチドまたはその塩を含む、医薬: (a)配列番号1で表されるアミノ酸配列を含むペプチド、 (b)配列番号1で表されるアミノ酸配列と60%以上の同一性を有するアミノ酸配列を含み、かつ、IL-18活性の阻害作用を有するペプチド、 (c)配列番号1で表されるアミノ酸配列において、1個または複数個のアミノ酸残基が欠失、置換、挿入および/または付加されたアミノ酸配列を含み、かつ、IL-18活性の阻害作用を有するペプチド、を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)