Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2017098529) NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/098529 International Application No.: PCT/IN2016/050436
Publication Date: 15.06.2017 International Filing Date: 06.12.2016
IPC:
C07K 9/00 (2006.01) ,A61K 38/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
9
Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14
Peptides containing saccharide radicals; Derivatives thereof
Applicants:
BHARAT BIOTECH INTERNATIONAL LIMITED [IN/IN]; Genome Valley, Turkapally, Shameerpet, Hyderabad 500078, IN
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH [IN/IN]; Anusandhan Bhawan, 2 Rafi Marg New Delhi 110001, IN
Inventors:
ELLA, Krishna Murthy; IN
BRUNDA, Ganneru; IN
KUMAR, Halmathur Mahabalarao Sampath; IN
SREEKANTH, Miryala; IN
Agent:
HASAN, Afzal; IN
HASAN, Vatsala Singh; IN
Priority Data:
6436/CHE/201510.12.2015IN
Title (EN) NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
(FR) NOUVEAU COMPOSÉ DÉRIVÉ DE MURAMYLE, SYNTHÈSE ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof. R = alkyl (both linear and branched), aryl, substituted aryl, alkoxy alkyl Wherein, R can be both linear and branched alkyl, aryl, substituted aryl and alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.
(FR) L'invention concerne un nouveau composé dérivé de muramyldipeptide (MDP) de formule développée VIII, un procédé de synthèse, des intermédiaires utilisés dans la synthèse et leur utilisation. R = groupes alkyle (à la fois linéaire et ramifié), aryle, aryle substitué, alcoxy alkyle, où R peut être un groupe alkyle à la fois linéaire et ramifié, aryle, aryle substitué et alkyle alcoxy. Ces composés possèdent d'excellentes propriétés pharmacologiques, notamment des propriétés immunomodulatrices pour une utilisation en tant qu'adjuvant dans des formulations de vaccins. Ces composés sont particulièrement utiles en tant qu'adjuvants dans des vaccins.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IN201847011474EP3387005CN108884132US20180371023ID2019/00204