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1. (WO2017098516) VARIANTS OF AMYLOID beta-PROTEIN PRECURSOR INHIBITOR DOMAIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/098516 International Application No.: PCT/IL2016/051318
Publication Date: 15.06.2017 International Filing Date: 08.12.2016
IPC:
C07K 14/81 (2006.01) ,A61K 38/55 (2006.01) ,A61P 35/00 (2006.01) ,G01N 33/48 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55
Protease inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
Applicants:
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD. [IL/IL]; Bldg. 39, Ben Gurion University of the Negev 84105 Beer-Sheva, IL
Inventors:
PAPO, Niv; IL
COHEN, Itay; IL
SANANES, Amiram; IL
Agent:
KESTEN, Dov; IL
GASSNER, Dvir; IL
GEYRA, Assaf; IL
Priority Data:
62/265,71910.12.2015US
62/313,82428.03.2016US
Title (EN) VARIANTS OF AMYLOID beta-PROTEIN PRECURSOR INHIBITOR DOMAIN
(FR) VARIANTES DU DOMAINE INHIBITEUR DU PRÉCURSEUR DE LA BÊTA-PROTÉINE AMYLOÏDE
Abstract:
(EN) Variants of amyloid ∮-protein precursor inhibitor domain (A PPI), effective in inhibiting mesotrypsin and/or kallikrein-6, and composition comprising same, are provided. Further, methods of use of said peptides or composition, including, but not limited to treatment of cancer are provided.
(FR) L'invention concerne des variantes du domaine inhibiteur du précurseur de la bêta-protéine amyloïde (APPI), efficaces pour inhiber la mésotrypsine et/ou la kallikréine-6, et une composition les contenant. L'invention concerne également des méthodes d'utilisation desdits peptides ou de ladite composition, notamment mais non exclusivement pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL259858EP3387012CN108699134US20180362616