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1. (WO2017098467) METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/098467 International Application No.: PCT/IB2016/057498
Publication Date: 15.06.2017 International Filing Date: 09.12.2016
Chapter 2 Demand Filed: 09.10.2017
IPC:
A61K 31/277 (2006.01) ,A61K 31/325 (2006.01) ,A61K 31/352 (2006.01) ,A61K 31/4025 (2006.01) ,A61K 31/443 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/28 (2006.01) ,A61P 25/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
325
Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
443
containing a five-membered ring with oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
Applicants:
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH [IN/IN]; Jakkur, Karnataka Bangalore 560064, IN
Inventors:
MANJITHAYA, Ravi; IN
MISHRA, Piyush; IN
SANTHI NATESAN, Suresh; IN
BATS, Somya; IN
AMMANATHAN, Veena; IN
CHAVALMANE, Aravinda; IN
Agent:
MUKHARYA, Durgesh; IN
BHOLA, Ravi; IN
RAVINDRANATH, Meenakshi; IN
RANGANATH, Shivakumar; IN
CHOTIA, Meenakshi; IN
J, Vikas; IN
RAJAGOPAL, Lakshmi; IN
RAO, Ramya Raghavendra,; IN
SURIYA, Naveen; IN
THIPPAPPA, Madhusudan, Siddara; IN
Priority Data:
6596/CHE/201509.12.2015IN
Title (EN) METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF
(FR) PROCÉDÉ DE MODULATION DE L’AUTOPHAGIE ET APPLICATIONS DE CELUI-CI
Abstract:
(EN) The present disclosure relates to method of modulating autophagy by modulators of autophagy, wherein the autophagy includes but is not limited to macroautophagy, chaperone mediated autophagy and microautophagy. The present disclosure further relates to modulators of autophagy for increasing or decreasing the autophagic flux. The disclosure also relates to modulator per se in modulating autophagy including but not limiting to macroautophagy, chaperon mediated autophagy and microautophagy.
(FR) La présente invention concerne un procédé de modulation de l'autophagie par des modulateurs d'autophagie, l'autophagie comprenant, sans limitation, la macro-autophagie, l'autophagie médiée par chaperon et la micro-autophagie. La présente invention concerne en outre des modulateurs d'autophagie pour augmenter ou diminuer le flux autophagique. L'invention concerne en outre un modulateur, en tant que tel, dans la modulation de l'autophagie comprenant, sans limitation, la macro-autophagie, l'autophagie médiée par chaperon et la micro-autophagie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016366810SG11201804884PEP3386498US20180369186