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1. (WO2017098430) NEW PROCESS AND INTERMEDIATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/098430 International Application No.: PCT/IB2016/057435
Publication Date: 15.06.2017 International Filing Date: 08.12.2016
IPC:
C07D 267/02 (2006.01) ,C07D 207/36 (2006.01) ,C07C 57/46 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
267
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
02
Seven-membered rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30
having two double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36
Oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
57
Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
46
containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
Applicants:
NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel, CH
Inventors:
KLEINBECK-RINIKER, Florian Karl; CH
MARTIN, Benjamin; CH
PENN, Gerhard; CH
VENTURONI, Francesco; CH
SCHLAMA, Thierry; CH
RUCH, Thomas; CH
ALLMENDINGER, Thomas; CH
WIETFELD, Bernhard; CH
FILIPPONI, Paolo; CH
Agent:
LARBIG, Karen D.; CH
Priority Data:
15199378.910.12.2015EP
16198655.914.11.2016EP
Title (EN) NEW PROCESS AND INTERMEDIATES
(FR) NOUVEAU PROCÉDÉ ET COMPOSÉS INTERMÉDIAIRES
Abstract:
(EN) The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
(FR) La présente invention concerne une synthèse chimique, des intermédiaires chimiques et des catalyseurs employés dans la préparation du sacubitril, inhibiteur de la néprilysine (NEP). L'invention concerne en outre de nouveaux composés intermédiaires et leur utilisation pour ladite nouvelle voie de synthèse chimique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016366795CA3006254IL259454KR1020180093984CN108602785EP3386955
US20180354889