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1. (WO2017098291) PROCESS FOR THE PURIFICATION OF 10-DEACETYL BACCATIN III
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/098291 International Application No.: PCT/HU2016/050061
Publication Date: 15.06.2017 International Filing Date: 12.12.2016
Chapter 2 Demand Filed: 11.10.2017
IPC:
C07D 305/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
305
Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
14
condensed with carbocyclic rings or ring systems
Applicants:
ROTACHROM TECHNOLÓGIAI KFT. [HU/HU]; Park u. 6. 2370 Dabas, HU
Inventors:
LORÁNTFY, László; HU
NÉMETH, László; HU
Agent:
KOVÁRI LLC; Attila út 125. 1012 Budapest, HU
Priority Data:
P150060311.12.2015HU
Title (EN) PROCESS FOR THE PURIFICATION OF 10-DEACETYL BACCATIN III
(FR) PROCÉDÉ DE PURIFICATION DE 10-DÉACÉTYL BACCATINE III
Abstract:
(EN) The subject of the invention relates to a centrifugal partition chromatography (CPC) method serving for separating 10- deacetylbaccatin III, where the solution to be purified containing 10-deacetylbaccatin III is purified in at least one CPC procedurial step, and where during the CPC procedurial step one of the following is used as the solvent mixture: MEK/water, MTBE/acetone/water, and DCM/MeOH/water. The subject of the invention also relates to 10- deacetylbaccatin III solution produced with the method.
(FR) L'invention concerne un procédé de chromatographie de partage centrifuge (CPC) permettant de séparer la 10-déacétyl baccatine III, la solution à purifier contenant de la 10-déacétyl baccatine III étant purifiée au cours d’au moins une étape CPC procédurale. Pendant l'étape CPC procédurale, l’une des combinaisons suivantes est utilisée comme mélange de solvant : MEK/eau, MTBE/acétone/eau ou DCM/MeOH/eau. L'invention concerne également une solution de 10-déacétyl baccatine III produite grâce au procédé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Hungarian (HU)
Also published as:
CN108602790EP3386957IN201817025757