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Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2016/080354 P33285-WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
09 December 2016 11 December 2015
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61K 31/4418 (2006.01)i; A61P 11/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
G. JIA ET AL, "P23 Target And Biomarker Discovery For Hedgehog Pathway Activity In Idiopathic Pulmonary Fibrosis In Support Of A Phase 2 Randomised, Double-blind, Placebo-controlled Study To Assess Efficacy And Safety Of Vismodegib In Ipf (island)", THORAX,Vol. 69, No. Suppl 2, 10 November 2014 (2014-11-10), page A87-A87,
US 7635707 B1 (BRADFORD WILLIAMSON ZIEGLER [US] ET AL) 22 December 2009 (2009-12-22)
claims 1, 47, 55
WUYTS WIM A ET AL, "Combination therapy: the future of management for idiopathic pulmonary fibrosis?", THE LANCET. RESPIRATORY MEDICINE, THE LANCET PUBLISHING GROUP, GB,Vol. 2, No. 11, 01 November 2014 (2014-11-01), page 933-942,
bottom;page 937, left-hand column
bottom;page 939, right-hand column
table 1
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
US 7635707 B1
22 December 2009
AT 503480 T
AU 2009313302 A1
AU 2010212371 A1
AU 2011200385 A1
BR PI0921022 A2
CA 2709997 A1
CA 2765402 A1
CN 102209543 A
CO 6382132 A2
CU 20110100 A7
CY 1111595 T1
DK 2191831 T3
DK 2343070 T3
EA 201170669 A1
EC SP11011039 A
EP 2191831 A1
EP 2343070 A1
EP 2500019 A1
EP 2505199 A1
ES 2387421 T3
ES 2525543 T3
ES 2578715 T3
HK 1145138 A1
HK 1153668 A1
HR P20110478 T1
HR P20141224 T1
IL 212064 A
JP 2012193193 A
JP 2012508253 A
JP 2015007132 A
KR 20110094295 A
MA 32880 B1
PE 06832011 A1
PT 2191831 E
PT 2343070 E
RS 51787 B
SI 2191831 T1
SI 2343070 T1
SM T201100030 B
SM T201500088 B
SV 2011003897 A
TN 2011000217 A1
TW 201020232 A
TW 201341361 A
US 7635707 B1
US 2011263656 A1
US 2012077850 A1
US 2014073673 A1
US 2016250198 A1
WO 2010054294 A1
ZA 201102411 B
15 April 2011
14 May 2010
09 September 2010
17 February 2011
29 December 2015
14 May 2010
14 May 2010
05 October 2011
15 February 2012
31 January 2012
07 October 2015
20 June 2011
05 January 2015
31 October 2011
29 July 2011
02 June 2010
13 July 2011
19 September 2012
03 October 2012
21 September 2012
26 December 2014
29 July 2016
19 August 2011
27 March 2015
31 July 2011
27 March 2015
30 June 2016
11 October 2012
05 April 2012
15 January 2015
23 August 2011
01 December 2011
20 October 2011
24 May 2011
14 January 2015
31 December 2011
29 July 2011
30 January 2015
09 September 2011
05 May 2015
09 August 2011
17 December 2012
01 June 2010
16 October 2013
22 December 2009
27 October 2011
29 March 2012
13 March 2014
01 September 2016
14 May 2010
25 June 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
27 February 2017
Date of mailing of the international search report:
10 March 2017
Authorized officer:
Baumgärtner, Heike
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