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1. (WO2017097871) HEXAHYDROPYRAZINOTRIAZINONE DERIVATIVES AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097871 International Application No.: PCT/EP2016/080168
Publication Date: 15.06.2017 International Filing Date: 08.12.2016
IPC:
C07D 487/04 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
UCB BIOPHARMA SPRL [BE/BE]; 60, Allée de la Recherche 1070 Brussels, BE
KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; K.U. Leuven R&D KU Leuven Research & Development Waaistraat 6 3000 Leuven, BE
Inventors:
HORSLEY, Helen Tracey; GB
MEARS, Richard John; GB
NEUSS, Judi Charlotte; GB
REUBERSON, James Thomas; GB
Agent:
UCB INTELLECTUAL PROPERTY; c/o UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data:
1521767.210.12.2015GB
Title (EN) HEXAHYDROPYRAZINOTRIAZINONE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS D’HEXAHYDRO-PYRAZINO-TRIAZINONE COMME INHIBITEURS DE KINASE
Abstract:
(EN) A series of 1,2,6,7,9,9a-hexahydropyrazino[1,2-d][1,2,4]triazin-4-one derivatives, substituted in the 8-position by an optionally substituted fused bicyclic heteroaromatic group, and in the 3-position by a range of functional groups,being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
(FR) L’invention concerne une série de dérivés de 1,2,6,7,9,9a-hexahydro-pyrazino[1,2-d][1,2,4]triazin-4-one, substituée en position 8 par un groupe hétéroaromatique bicyclique fusionné éventuellement substitué, et en position 3 par différents groupes fonctionnels, étant des inhibiteurs sélectifs de l’activité phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ), étant utiles dans le traitement et/ou la prévention de diverses maladies humaines, comprenant des troubles inflammatoires, auto-immuns et oncologiques ; des maladies virales et du paludisme ; et le rejet de greffe d'organes et de cellules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3007975IN201817021965EP3386984CN108699064US20180362532BR112018011656
EA201891349