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1. (WO2017097792) 2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097792 International Application No.: PCT/EP2016/079973
Publication Date: 15.06.2017 International Filing Date: 07.12.2016
IPC:
C07D 471/04 (2006.01) ,A61K 31/437 (2006.01) ,A61P 11/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin, DE
Inventors:
DELBECK, Martina; DE
HAHN, Michael; DE
MÜLLER, Thomas; DE
MEIER, Heinrich; DE
LUSTIG, Klemens; DE
MOSIG, Johanna; DE
TOSCHI, Luisella; DE
ALBUS, Udo; DE
GEHRING, Doris; DE
ROSENSTEIN, Björn; DE
Agent:
BIP PATENTS; c/o Bayer Intellectual Property GmbH Alfred-Nobel-Str. 10 40789 Monheim am Rhein, DE
Priority Data:
15199270.810.12.2015EP
16196836.702.11.2016EP
Title (DE) 2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDIN-DERIVATE ALS BLOCKER DER TASK-1 UND TASK-2 KANÄLE ZUR BEHANDLUNG VON SCHLAFBEDINGTEN ATEMSTÖRUNGEN
(EN) 2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS
(FR) DÉRIVÉS DE 2-PHÉNYL-3-(PIPÉRAZINOMÉTHYL)IMIDAZO[1,2-A]PYRIDINE UTILISÉS COMME BLOQUEURS DES CANAUX TASK-1 ET TASK-2 POUR TRAITER DES TROUBLES RESPIRATOIRES LIÉS AU SOMMEIL
Abstract:
(DE) Die vorliegende Anmeldung offenbart 2-Phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridin-Derivate als selektive Blocker der TASK-1 und TASK-3 Kanäle zur Behandlung und/oder Prävention von Atemstörungen, einschließlich schlafbedingter Atemstörungen wie obstruktiven und zentralen Schlafapnoen und Schnarchen.
(EN) The invention relates to 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives as selective blockers of TASK-1 and TASK-3 channels, for the treatment and/or prevention of breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.
(FR) La présente invention concerne des dérivés de 2-phényl-3-(pipérazinométhyl)imidazo[1,2-a]pyridine utilisés comme bloqueurs sélectifs des canaux TASK-1 et TASK-2 pour traiter et/ou prévenir des troubles respiratoires, notamment des troubles respiratoires liés au sommeil tels que les apnées obstructive et centrale du sommeil et le ronflement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
UAa201807756AU2016365676CA3007724SG11201804449WDOP2018000142IL259374
CN108290887MYPI 2018702270ID2018/09107IN201817018005EP3386979KR1020180088462
BR112018011783EA201891374US20190062326