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1. (WO2017097251) TWO OPTICALLY PURE ISOMERS NK007, AND SYNTHESIS AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097251 International Application No.: PCT/CN2016/109174
Publication Date: 15.06.2017 International Filing Date: 09.12.2016
IPC:
C07D 471/04 (2006.01) ,C07C 51/41 (2006.01) ,C07C 59/245 (2006.01) ,A01N 43/90 (2006.01) ,A61K 31/437 (2006.01) ,A61P 37/02 (2006.01) ,A61P 29/00 (2006.01) ,A61P 19/02 (2006.01) ,A01P 1/00 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
41
Preparation of salts of carboxylic acids by conversion of the acids or their salts into salts with the same carboxylic acid part
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
235
Saturated compounds having more than one carboxyl group
245
containing hydroxy or O-metal groups
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90
having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
P
BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
1
Disinfectants; Antimicrobial compounds or mixtures thereof
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
南开大学 NANKAI UNIVERSITY [CN/CN]; 中国天津市 南开区卫津路94号 No.94 Weijin Road, Nankai District Tianjin 300071, CN
Inventors:
汪清民 WANG, Qingmin; CN
尹芝南 YIN, Zhinan; CN
王兹稳 WANG, Ziwen; CN
洪章勇 HONG, Zhangyong; CN
刘玉秀 LIU, Yuxiu; CN
温倜 WEN, Chou; CN
宋红健 SONG, Hongjian; CN
郑彦龙 ZHENG, Yanlong; CN
Agent:
北京润平知识产权代理有限公司 RUNPING&PARTNERS; 中国北京市 海淀区北四环西路9号,银谷大厦515室 Suite 515, Yingu Mansion, No.9 Beisihuanxilu, Haidian District Beijing 100190, CN
Priority Data:
201510930297.611.12.2015CN
Title (EN) TWO OPTICALLY PURE ISOMERS NK007, AND SYNTHESIS AND APPLICATION THEREOF
(FR) DEUX ISOMÈRES NK007 OPTIQUEMENT PURS, SYNTHÈSE ET APPLICATION CORRESPONDANTES
(ZH) NK007的两个光学纯异构体及其合成和应用
Abstract:
(EN) The present invention relates to two optically pure isomers called NK007 for short, synthesis thereof, and an application thereof in the protection against plant viruses and the regulation of immunological activity. Compounds NK007-1 and NK007-2 of the present invention have good activity against tobacco leaf viruses, and can be used for treating plant virus diseases. The compounds NK007-1 and NK007-2 of the present invention have good activity in immune regulation, and can be used for the preparation of a drug for treating rheumatic arthritis. A method for testing the activity of a compound in immune regulation of the present invention can be used for screening novel arthritis drugs.
(FR) La présente invention concerne deux isomères optiquement purs appelés NK007 en abrégé, leur synthèse et une application correspondante dans la protection contre des virus de plantes et la régulation de l'activité immunologique. Les composés NK007-1 et NK007-2 de la présente invention présentent une bonne activité contre les virus de feuilles de tabac et peuvent être utilisés pour traiter des maladies virales des plantes. Les composés NK007-1 et NK007-2 de la présente invention présentent une bonne activité dans la régulation immune et peuvent être utilisés pour la préparation d'un médicament destiné au traitement de l'arthrite rhumatismale. Un procédé pour tester l'activité d'un composé dans la régulation immune de la présente invention peut être utilisé pour le criblage de nouveaux médicaments contre l'arthrite.
(ZH) 本发明涉及简称为NK007的两个光学纯异构体及其合成以及它们在抗植物病毒和调节免疫活性方面的应用。本发明中化合物NK007-1和NK007-2具有很好的抗烟草花叶病毒活性,能够用于治疗植物病毒病害。本发明中化合物NK007-1和NK007-2具有很好的调节免疫活性,能够用于制备治疗风湿性关节炎的药物。本发明测试化合物调节免疫活性的方法,能够用于新型关节炎药物的筛选。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)