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1. (WO2017097216) FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097216 International Application No.: PCT/CN2016/108964
Publication Date: 15.06.2017 International Filing Date: 07.12.2016
IPC:
C07D 401/14 (2006.01) ,C07D 417/14 (2006.01) ,C07D 413/14 (2006.01) ,A61K 31/444 (2006.01) ,A61K 31/497 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
苏州信诺维医药科技有限公司 SUZHOU SINOVENT PHARMACEUTICALS CO., LTD. [CN/CN]; 中国江苏省苏州市苏州工业园区星湖街218号B2楼511单元 Unit 511, Building B2 No. 218 Xinhu Road, Suzhou Industrial Park Jiangsu 215123, CN
Inventors:
王永辉 WANG, Yonghui; CN
朱研 ZHU, Yan; CN
周娟 ZHOU, Juan; CN
高羽军 GAO, Yujun; CN
王士群 WANG, Shiqun; CN
王栋 WANG, Dong; CN
刘万登 LIU, Wandeng; CN
沈锡明 SHEN, Ximing; CN
洪彬彬 HONG, Binbin; CN
刘涛 LIU, Tao; CN
吴耀东 WU, Yaodong; CN
李春启 LI, Chunqi; CN
Agent:
浙江杭州金通专利事务所有限公司 ZHEJIANG HANGZHOU JINTONG PATENT OFFICE CO., LTD; 中国浙江省杭州市下城区武林广场8号省科协大楼3层 Provincial Science And Technology Building, Wulin Square No.8, Xiacheng District Hangzhou, Zhejiang 310003, CN
Priority Data:
201510887508.207.12.2015CN
Title (EN) FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR
(FR) INHIBITEUR DE LA VOIE WNT AMIDES HÉTÉROCYCLIQUES À CINQ CHAÎNONS
(ZH) 五元杂环酰胺类WNT通路抑制剂
Abstract:
(EN) Disclosed in the present invention is a five-membered heterocyclic amides Wnt pathway inhibitor, belonging to compounds that regulate the activities of a Wnt signaling pathway, and a method for preparing such compounds and use of such compounds in preparing drugs for antagonizing a Wnt signaling pathway are provided. The five-membered heterocyclic amides Wnt pathway inhibitor provided in the present invention has remarkable anti-tumor activities on the basis of a rational drug design for targets, and can be used in developing a new generation of Wnt pathway inhibitor, having a high clinical application value and a considerable market potential.
(FR) La présente invention concerne un inhibiteur de la voie Wnt amides hétérocycliques à cinq chaînons, appartenant à des composés qui régulent les activités d'une voie de signalisation Wnt, ainsi qu'un procédé de préparation de ces composés et l'utilisation de tels composés dans la préparation de médicaments pour antagoniser une voie de signalisation Wnt. L'inhibiteur de la voie Wnt amides hétérocycliques à cinq chaînons décrit dans la présente invention présente de remarquables activités anti-tumorales sur la base d'une conception rationnelle de médicaments pour des cibles, et peut être utilisé pour développer une nouvelle génération d'inhibiteur de la voie Wnt, présentant une grande valeur d'application clinique et un potentiel de commercialisation considérable.
(ZH) 本发明公开了一种五元杂环酰胺类WNT通路抑制剂,属于调节Wnt信号通路活性的化合物,并提供了该类化合物的制备方法,及该类化合物在制备拮抗Wnt信号通路的药物中的应用。本发明提供的五元杂环酰胺类WNT通路抑制剂,基于靶标的合理药物设计,抗肿瘤活性显著,可用于开发成新一代的Wnt通路抑制剂,具有极大的临床应用价值,市场潜力可观。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
AU2016368257KR1020180094880US20180271846EP3388428