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1. (WO2017097194) COMPLETELY-SOLID-PHASE PREPARATION METHOD FOR CARBETOCIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097194 International Application No.: PCT/CN2016/108824
Publication Date: 15.06.2017 International Filing Date: 07.12.2016
IPC:
C07K 7/16 (2006.01) ,C07K 1/06 (2006.01) ,C07K 1/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
16
Oxytocins; Vasopressins; Related peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
06
using protecting groups or activating agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
04
on carriers
Applicants:
深圳翰宇药业股份有限公司 HYBIO PHARMACEUTICAL CO., LTD. [CN/CN]; 中国广东省深圳市 南山区高新技术工业园中区翰宇生物医药园办公大楼四层 4th Floor, Hybio Medicine Park Office Building, High-tech Industrial Park Central District, Nanshan Shenzhen, Guangdong 518057, CN
Inventors:
姚志军 YAO, Zhijun; CN
马婧思 MA, Jingsi; CN
伍柯瑾 WU, Kejin; CN
宓鹏程 MI, Pengcheng; CN
陶安进 TAO, Anjin; CN
袁建成 YUAN, Jiancheng; CN
Agent:
北京市诚辉律师事务所 BEIJING CHENGHUI LAW FIRM; 中国北京市 朝阳区朝阳北路99号楼2单元905 905, Tower 2, No.99 Chaoyang North Road, Chaoyang District Beijing 100123, CN
Priority Data:
201510897391.608.12.2015CN
Title (EN) COMPLETELY-SOLID-PHASE PREPARATION METHOD FOR CARBETOCIN
(FR) PROCÉDÉ, ENTIÈREMENT EN PHASE SOLIDE, DE PRÉPARATION DE CARBÉTOCINE
(ZH) 一种全固相制备卡贝缩宫素的方法
Abstract:
(EN) Provided is a completely-solid-phase preparation method for carbetocin, comprising: first, coupling chloro-butyric acid to tyrosine amino of a peptide chain through an amide coupling agent; and then, performing solid-phase cyclization by using DBU as a base to obtain a crude carbetocin peptide.
(FR) L'invention concerne un procédé, entièrement en phase solide, de préparation de carbétocine, comprenant les étapes consistant d'abord à coupler de l'acide chloro-butyrique à l'aminotyrosine d'une chaîne peptidique par l'intermédiaire d'un agent de couplage amide; puis à procéder à une cyclisation en phase solide en utilisant du DBU comme base pour obtenir un peptide de type carbétocine brute.
(ZH) 提供一种卡贝缩宫素的全固相制备方法,先将氯代丁酸通过酰胺偶联与肽链的酪氨酸氨基偶联,然后采用DBU为碱在固相上进行环化得到卡贝缩宫素粗肽。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)