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1. (WO2017097187) COMPOUND, PREPARATION METHOD THEREFOR, APPLICATIONS THEREOF, CORRESPONDING TARGETED DRUG DELIVERY SYSTEM, CHEMOTHERAPY DRUGS, AND TREATMENT METHOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097187 International Application No.: PCT/CN2016/108717
Publication Date: 15.06.2017 International Filing Date: 06.12.2016
IPC:
C07C 235/64 (2006.01) ,C07C 231/12 (2006.01) ,A61K 31/167 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44
with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
58
with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring
64
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
12
by reactions not involving the formation of carboxamide groups
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
北京信德润兴科技有限公司 BEIJING XINDE RUNXING TECHNOLOGY CO., LTD. [CN/CN]; 中国北京市 大兴区经济技术开发区科创四街36号院5号楼3A13 Room 3A13, Building 5 No. 36, Kechuang Fourth Street, Beijing Economic and Development Zone, Daxing District Beijing 100176, CN
Inventors:
卢学春 LU, Xuechun; CN
迟小华 CHI, Xiaohua; CN
唐诚成 TANG, Chengcheng; CN
施磊 SHI, Lei; CN
Agent:
北京市隆安律师事务所 BEIJING LONGAN LAW FIRM; 中国北京市 朝阳区建国门外大街21号北京国际俱乐部188室 Room 188, Beijing International Club 21 Jianguomenwai Street, Chaoyang District Beijing 100020, CN
Priority Data:
201510888021.607.12.2015CN
Title (EN) COMPOUND, PREPARATION METHOD THEREFOR, APPLICATIONS THEREOF, CORRESPONDING TARGETED DRUG DELIVERY SYSTEM, CHEMOTHERAPY DRUGS, AND TREATMENT METHOD
(FR) COMPOSÉ, SON PROCÉDÉ DE PRÉPARATION, SES APPLICATIONS, SYSTÈME D'ADMINISTRATION DE MÉDICAMENT CIBLÉ CORRESPONDANT, MÉDICAMENTS CHIMIOTHÉRAPEUTIQUES, ET PROCÉDÉ DE TRAITEMENT
(ZH) 一种化合物及其制备方法和用途及相应的靶向给药系统和化疗药物以及治疗方法
Abstract:
(EN) The present invention relates to a compound, a preparation method therefor, applications thereof, a corresponding targeted drug delivery system, and chemotherapy drugs. The compound is a novel compound for treating a small cell lung cancer or a pharmaceutically-acceptable salt of the compound. The present invention is characterized in that the compound has formula I, R beng acyloxy. The present invention further relates to the preparation method for the compound, a method for treating the small cell lung cancer, a targeted drug delivery system comprising the compound, and chemotherapy drugs that contains the compound and that is used for treating the small cell lung cancer.
(FR) La présente invention concerne un composé, son procédé de préparation, ses applications, un système correspondant d'administration de médicament ciblé, et des médicaments chimiothérapeutiques. Le composé est un nouveau composé de traitement d'un cancer du poumon à petites cellules ou un sel pharmaceutiquement acceptable du composé. La présente invention est caractérisée en ce que le composé présente la formule I, R étant un groupe acyloxy. La présente invention concerne en outre le procédé de préparation du composé, un procédé de traitement du cancer du poumon à petites cellules, un système d'administration de médicament ciblé comprenant le composé, et des médicaments chimiothérapeutiques qui contiennent le composé et qui est utilisé pour traiter le cancer du poumon à petites cellules.
(ZH) 本发明涉及一种化合物及其制备方法和用途及相应的靶向给药系统和化疗药物,所述化合物为用于治疗小细胞肺癌的新型化合物或其药学上可接受的盐,其特征在于,所述化合物具有式I:其中R为酰氧基;还涉及所述化合物的制备方法,涉及治疗小细胞肺癌的治疗方法,还涉及包含所述化合物的靶向给药系统,以及涉及包含所述化合物的治疗小细胞肺癌的化疗药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
US20180346409