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1. (WO2017097113) AMINOPYRIMIDINE COMPOUNDS FOR INHIBITING ACITIVITY OF PROTEIN TYROSINE KINASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/097113 International Application No.: PCT/CN2016/107072
Publication Date: 15.06.2017 International Filing Date: 24.11.2016
IPC:
C07D 401/12 (2006.01) ,C07D 239/48 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/5377 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
48
Two nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
深圳市塔吉瑞生物医药有限公司 SHENZHEN TARGETRX, INC. [CN/CN]; 中国广东省深圳市 南山区科苑路15号科兴科学园A1栋301 Room 301, Building A1, Kexing Science Park No.15 of Keyuan Road, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors:
王义汉 WANG, Yihan; CN
李焕银 LI, Huanyin; CN
Agent:
北京市柳沈律师事务所 LIU, SHEN & ASSOCIATES; 中国北京市 海淀区彩和坊路10号1号楼10层 10th Floor, Building 1 10 Caihefang Road, Haidian District Beijing 100080, CN
Priority Data:
201510916776.210.12.2015CN
Title (EN) AMINOPYRIMIDINE COMPOUNDS FOR INHIBITING ACITIVITY OF PROTEIN TYROSINE KINASE
(FR) COMPOSÉS D’AMINOPYRIMIDINE POUR L’INHIBITION DE L’ACTIVITÉ DE PROTÉINE TYROSINE KINASE
(ZH) 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物
Abstract:
(EN) The present invention relates to aminopyrimidine compounds capable of inhibiting the activity of protein tyrosine kinase, and to preparation and uses thereof. Specifically, disclosed are an aminopyrimidine compound shown in Formula (I), and a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form, a prodrug, or an isotope-variant medicine composition, comprising the compound. The compound in the present invention can be used for treating and/or preventing protein tyrosine kinase related diseases such as cell proliferative diseases, cancers, and immune diseases.
(FR) La présente invention concerne des composés d’aminopyrimidine pouvant inhiber l’activité de protéine tyrosine kinase, ainsi que leur préparation et leurs utilisations. Plus précisément, l’invention concerne un composé d’aminopyrimidine représenté par la formule (I) et un sel de qualité pharmaceutique, un stéréo-isomère, un solvate, un hydrate, une forme cristalline, un promédicament ou une composition médicinale isotopiquement variante comportant le composé. Le composé selon la présente invention peut être utilisé pour le traitement et/ou la prévention de maladies liées aux protéine tyrosine kinases telles que des maladies liées à la prolifération de cellules, des cancers et des maladies du système immunitaire.
(ZH) 本发明涉及对蛋白酪氨酸激酶活性具有抑制作用的氨基嘧啶类化合物,以及涉及它们的制备和用途。具体地,该发明公开了式(I)所示的氨基嘧啶类化合物以及含有该化合物、其药学上可接受的盐、立体异构体、溶剂合物、水合物、晶型、前药或同位素变体的药物组合物。本发明化合物可用于治疗和/或预防蛋白酪氨酸激酶相关性疾病,例如细胞增殖性疾病、癌症、免疫性疾病。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
CN108137544