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1. (WO2017096383) FACTOR VIII WITH EXTENDED HALF-LIFE AND REDUCED LIGAND-BINDING PROPERTIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/096383 International Application No.: PCT/US2016/064979
Publication Date: 08.06.2017 International Filing Date: 05.12.2016
IPC:
C07K 14/755 (2006.01) ,A61K 47/61 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
745
Blood coagulation or fibrinolysis factors
755
Factors VIII
[IPC code unknown for A61K 47/61]
Applicants:
BAXALTA INCORPORATED [US/US]; 1200 Lakeside Drive Bannockburn, IL 60015, US
BAXALTA GMBH [CH/CH]; Thurgauerstrasse 130 8152 Glattpark (Opfikon), CH
Inventors:
TURECEK, Peter; AT
SCHRENK, Gerald; AT
SIEKMANN, Juergen; AT
Agent:
MANN, Jeffry, S.; US
ESKER, Todd; US
KWAK, Byung, Cheol; US
MACDOUGALL, Christina, A.; US
ANTCZAK, Andy, J.; US
Priority Data:
62/262,67403.12.2015US
Title (EN) FACTOR VIII WITH EXTENDED HALF-LIFE AND REDUCED LIGAND-BINDING PROPERTIES
(FR) FACTEUR VIII À DEMI-VIE PROLONGÉE ET À PROPRIÉTÉS DE LIAISON AUX LIGANDS RÉDUITES
Abstract:
(EN) The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to a modified, recombinant Factor VIII (FVIII) with extended half-life and reduced ligand-binding properties.
(FR) L'invention porte sur des matières et procédés de conjugaison d'un polymère soluble dans l'eau à une fraction glucidique oxydée d'une protéine thérapeutique comprenant la mise en contact de la fraction glucidique oxydée avec un polymère soluble dans l'eau activé dans des conditions qui permettent la conjugaison. Plus précisément, la présente invention concerne un facteur VIII (FVIII) recombinant modifié à demi-vie prolongée et à propriétés de liaison aux ligands réduites.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016362606CA3007364SG11201804666QMYPI 2018000857IL259760KR1020180088727
EP3383895ID2018/12614CN108884146BR112018011259EA201891333PH1/2018/501174