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1. (WO2017096323) PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/096323 International Application No.: PCT/US2016/064854
Publication Date: 08.06.2017 International Filing Date: 02.12.2016
IPC:
A61K 31/44 (2006.01) ,A01N 43/42 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
34
having rings with one nitrogen atom as the only ring hetero atom
40
six-membered rings
42
condensed with carbocyclic rings
Applicants:
ASTRAEA THERAPEUTICS, LLC [US/US]; 320 Logue Avenue, Suite 131 Mountain View, CA 94043, US
ZAVERI, Nurulain, T. [US/US]; US
MEYER, Michael [US/US]; US
JOURNIGAN, V., Blair [US/US]; US
YASUDA, Dennis [US/US]; US
Inventors:
ZAVERI, Nurulain, T.; US
MEYER, Michael; US
JOURNIGAN, V., Blair; US
YASUDA, Dennis; US
Agent:
SINGH, Sunil, K.; US
Priority Data:
62/261,87102.12.2015US
Title (EN) PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS
(FR) COMPOSÉS DE PIPÉRIDINYLE POUR RÉCEPTEUR DE NOCICEPTINE
Abstract:
(EN) The present invention provides novel piperidinyl-containing nociceptin receptor ligand compounds and pharmaceutical compositions useful in the treatment of neurological diseases and conditions where such ligands mediate the negative effects of the condition. Such neurological diseases and conditions include acute and chronic pain, substance abuse/dependence, alcohol addiction, anxiety, depression, sleep disorders, gastrointestinal disorders, renal disorders, cardiovascular disorders and Parkinson' s disease.
(FR) La présente invention concerne de nouveaux composés de type ligand pour récepteur de nociceptine contenant un pipéridinyle et des compositions pharmaceutiques utiles dans le traitement des maladies et des affections neurologiques où ces ligands régulent les effets négatifs de l'affection. Ces maladies et affections neurologiques comprennent la douleur aiguë et chronique, la toxicomanie/dépendance à une substance, l'alcoolisme, l'anxiété, la dépression, les troubles du sommeil, les troubles gastro-intestinaux, les troubles rénaux, les troubles cardiovasculaires et la maladie de Parkinson.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016365400CA3006966IL259726KR1020180094940EP3383390CN108883103