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1. (WO2017095993) METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/095993 International Application No.: PCT/US2016/064339
Publication Date: 08.06.2017 International Filing Date: 01.12.2016
IPC:
A61K 31/04 (2006.01) ,A61K 31/095 (2006.01) ,A61K 31/275 (2006.01) ,A61K 31/26 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
04
Nitro compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
095
Sulfur, selenium or tellurium compounds, e.g. thiols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
26
Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
Applicants:
THE PROCTER & GAMBLE COMPANY [US/US]; One Procter & Gamble Plaza Cincinnati, Ohio 45202, US
THE CLEVELAND CLINIC FOUNDATION [US/US]; 9500 Euclid Avenue Cleveland, Ohio 44195, US
Inventors:
HAZEN, Stanley, Leon; US
GARCIA-GARCIA, Jose Carlos; US
GERBERICK, George, Franklin; US
WOS, John, August; US
STANTON, David, Thomas; US
INGLIN, Thomas, Alfred; US
REILLY, Michael; US
DEUTSCH, Angela, Jane; US
REED, Jodie, Michelle; US
CODY, David, Blair; US
Agent:
KREBS, Jay A.; US
Priority Data:
62/261,64501.12.2015US
62/261,66201.12.2015US
62/356,42229.06.2016US
Title (EN) METHODS FOR INHIBITING CONVERSION OF CHOLINE TO TRIMETHYLAMINE (TMA)
(FR) PROCÉDÉS POUR INHIBER LA CONVERSION DE LA CHOLINE EN TRIMÉTHYLAMINE (TMA)
Abstract:
(EN) The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.
(FR) L'invention concerne un ou plusieurs procédés pour inhiber la conversion de la choline en triméthylamine (TMA) et abaisser le TMAO chez un sujet, comprenant l'administration audit sujet d'une ou de plusieurs compositions comprenant un composé représenté par la Formule (I) : le composé étant administré en une quantité efficace pour inhiber la formation de triméthylamine (TMA) à partir de choline chez le sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016365314CA3007081EP3383378CN108601753IN201817020456BR112018011216