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1. (WO2017095969) hTERT MODULATORS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/095969 International Application No.: PCT/US2016/064287
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
C07C 275/54 (2006.01) ,A01N 47/34 (2006.01) ,A61K 31/17 (2006.01) ,C07D 401/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
275
Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
46
containing any of the groups X being a hetero atom, Y being any atom, e.g. acylureas
48
Y being a hydrogen or a carbon atom
54
Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
47
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
08
the carbon atom having one or more single bonds to nitrogen atoms
28
Ureas or thioureas containing the groups N-CO-N or N-CS-N
34
containing the groups , e.g. biuret; Thio-analogues thereof; Urea-aldehyde condensation products
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
17
having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
THE ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA [US/US]; 220 W. 6th Street, University Services Annex 4th Floor Tucson, AZ 85721, US
Inventors:
HURLEY, Laurence; US
GOKHALE, Vijay; US
KANG, HyunJin; US
WU, Kui; US
Agent:
GOETZ, Robert A.; US
Priority Data:
62/261,83801.12.2015US
Title (EN) hTERT MODULATORS AND METHODS OF USE
(FR) MODULATEURS HTERT ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
(FR) La présente invention porte sur des modulateurs hTERT et sur leurs procédés de production et d'utilisation. En particulier, la présente invention concerne un composé de formule telle que définie dans la description. Certains aspects de l'invention reposent sur la caractérisation de l'effet de mutants de région promotrice centrale hTERT sur la structure G-quadruplex 5-12 et sa stabilité. Nous croyons que certains des composés de l'invention se lient sélectivement à la G-quadruplex dans le mutant de promoteur central hTERT, ce qui entraîne une inversion de l'effet d'activation de promoteur mutant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3006799EP3383841US20180346415