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1. (WO2017095918) METHODS FOR TREATING CANCER USING RSPO3 ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/095918 International Application No.: PCT/US2016/064207
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
C12Q 1/68 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
ONCOMED PHARMACEUTICALS, INC. [US/US]; 800 Chesapeake Drive Redwood City, California 94063, US
Inventors:
KAPOUN, Ann M.; US
ZHANG, Chun; US
WANG, Min; US
LIU, Yu-Wang; US
O'YOUNG, Gilbert; US
CATTARUZZA, Fiore; US
KAVANAGH, Joy; GB
McFARLANE, Cheryl; GB
McGEOWN, Michelle; GB
Agent:
CALVO, Paul A.; US
BANOWIT, Donald R.; US
BEZOS, Salvador M.; US
CIMBALA, Michelle A.; US
COLLER III, Richard D.; US
CORNWELL, David K.S.; US
COVERT, John M.; US
DESAI, Nirav N.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GILLENTINE, Marsha Rose; US
GOLDSTEIN, Jorge A.; US
GORDON, Lori A.; US
HELVEY, Jeffrey T.; US
HICKS, Ross G.; US
HOLOUBEK, Michelle K.; US
HOOVER, Kenley K.; US
JACKMAN, Peter A.; US
KIM, Ji-Eun; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MCGROARTY, John P.; US
MESSINGER, Michael V.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph E.; US
NANNENGA-COMBS, Bonnie; US
PICKARD, Byron L.; US
RAY, Michael B.; US
RYGIEL, Mark W.; US
SHEA, JR, Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STEFFE, Eric K.; US
STERLING, Deborah A.; US
STERNE, Robert Greene; US
STRANG, Jonathan M.; US
TUMINARO, Jonathan; US
VARUGHESE, Dennies; US
WRIGHT, Jon E.; US
YONAN, Daniel E.; US
ZHOU, Lei; US
Priority Data:
62/261,61801.12.2015US
62/308,57715.03.2016US
Title (EN) METHODS FOR TREATING CANCER USING RSPO3 ANTAGONISTS
(FR) PROCÉDÉS DE TRAITEMENT DU CANCER AU MOYEN D'ANTAGONISTES DE RSPO3
Abstract:
(EN) The present invention provides compositions for identifying tumors likely to respond to treatment with an RSPO3 antagonist (e.g., anti-RSPO3 antibody). Also provided are methods for identifying tumors and/or patients that are likely to be responsive or non-responsive to treatment with an RSPO3 antagonist (e.g., anti-RSPO3 antibody). Methods for treating a patient with cancer are provided, wherein the cancer is predicted to respond to an RSPO3 antagonist (e.g., anti-RSPO3 antibody).
(FR) La présente invention concerne des compositions permettant d'identifier des tumeurs susceptibles de répondre à un traitement avec un antagoniste de RSPO3 (par exemple un anticorps anti-RSPO3). L'invention concerne également des procédés d'identification de tumeurs et/ou de patients qui sont susceptibles de répondre ou de ne pas répondre au traitement avec un antagoniste de RSPO3 (par exemple un anticorps anti-RSPO3). L'invention concerne en outre des procédés de traitement d'un patient atteint d'un cancer, lorsqu'il est prévu que le cancer réponde à un antagoniste de RSPO3 (par exemple un anticorps anti-RSPO3).
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)