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1. (WO2017095899) GRADIENT MICROFLUIDIC DEVICES AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/095899 International Application No.: PCT/US2016/064179
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
B01L 3/00 (2006.01) ,C12M 1/00 (2006.01) ,C12M 1/12 (2006.01) ,C12M 1/34 (2006.01) ,C12M 3/00 (2006.01) ,C12M 3/04 (2006.01) ,C12M 3/06 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
12
with sterilisation, filtration, or dialysis means
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
34
Measuring or testing with condition measuring or sensing means, e.g. colony counters
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
04
with means providing thin layers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
06
with filtration, ultrafiltration, inverse osmosis or dialysis means
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138, US
Inventors:
INGBER, Donald, E.; US
JANG, Kyung-Jin; US
LEVNER, Daniel; US
WEN, Norman; US
Agent:
RESNICK, David, S.; US
CIMPOES, Sorinel; US
BURNHAM, Daniel, J.; US
Priority Data:
62/263,38604.12.2015US
Title (EN) GRADIENT MICROFLUIDIC DEVICES AND USES THEREOF
(FR) DISPOSITIFS MICROFLUIDIQUES À GRADIENT ET LEURS UTILISATIONS
Abstract:
(EN) A device simulates a function of a tissue and includes a first structure defining a first chamber, a second structure defining a plurality of second chambers, and a membrane located at an interface region between the first chamber and the plurality of second chambers. The second structure extends along the first chamber. Each of the second chambers has a fluid therein, with each fluid having an agent of a different concentration and/or flowing at a different flow rate. The membrane, which separates the first chamber from the plurality of second chambers, has cells adhered on a first side facing toward the first chamber and on a second side facing toward the plurality of second chambers.
(FR) L'invention concerne un dispositif qui simule une fonction d'un tissu et comprend une première structure définissant une première chambre, une seconde structure définissant une pluralité de secondes chambres, et une membrane située au niveau d'une région d'interface entre la première chambre et la pluralité de secondes chambres. La seconde structure s'étend le long de la première chambre. Chacune des secondes chambres renfermant un fluide, chaque fluide comprenant un agent d'une concentration différente et/ou s'écoulant à un débit différent. La membrane qui sépare la première chambre de la pluralité de secondes chambres a des cellules accrochées sur un premier côté dirigé vers la première chambre et sur un second côté dirigé vers la pluralité de secondes chambres.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)