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1. (WO2017095875) ANTI HUMAN IP-10 ANTIBODIES AND THEIR USES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/095875 International Application No.: PCT/US2016/064140
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
C07K 16/24 (2006.01) ,A61K 39/395 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 & Province Line Road Princeton, NJ 08543, US
Inventors:
SRINIVASAN, Mohan; US
DESHPANDE, Shrikant; US
ZHAO, Qihong; US
SUN, Huadong; US
RAKESTRAW, Ginger; US
CHEN, Guodong; US
HUANG, Richard, Y.; US
SHERIFF, Steven; US
RODRIGUEZ, Cristain; US
THROUP, John, P.; US
DIBELLA, Rose, A.; US
Agent:
REMILLARD, Jane, E.; US
DIGIORGIO, Jeanne, M.; US
REMILLARD, Jane, E.; US
FRANK, Christopher, L.; US
GASTONGUAY, Adam, J.; US
Priority Data:
62/261,21030.11.2015US
62/374,62212.08.2016US
Title (EN) ANTI HUMAN IP-10 ANTIBODIES AND THEIR USES
(FR) ANTICORPS ANTI IP-10 HUMAINE ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
(FR) La présente invention concerne des anticorps monoclonaux isolés, notamment des anticorps humains qui se lient à IP-10 avec une affinité élevée, inhibent la liaison de IP-10 à son récepteur, inhibent le flux de calcium induit par IP-10 et inhibent la migration cellulaire induite par IP-10. L'invention concerne également des molécules d'acide nucléique codant les anticorps de l'invention, des vecteurs d'expression, des cellules hôtes et des procédés pour exprimer les anticorps de l'invention. L'invention concerne en outre des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention. L'invention concerne également des procédés d'inhibition de l'activité d'IP-10 au moyen des anticorps de l'invention, notamment des procédés de traitement de diverses maladies inflammatoires et auto-immunes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020180083937EP3383903CN108602885