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1. (WO2017095324) CLINICAL CORRELATES OF IMMUNOTHERAPY EFFICACY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/095324 International Application No.: PCT/SG2016/050441
Publication Date: 08.06.2017 International Filing Date: 09.09.2016
Chapter 2 Demand Filed: 05.06.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/574 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis, Singapore 138632, SG
TESSA THERAPEUTICS PTE. LTD. [SG/SG]; 46 Kim Yam Road #01-14 The Herencia, Singapore 239351, SG
SINGAPORE HEALTH SERVICES PTE. LTD. [SG/SG]; 31 Third Hospital Avenue #03-03, Bowyer Block C, Singapore 168753, SG
Inventors:
CONNOLLY, John; SG
HOPKINS, Richard; SG
TOH, Han Chong; SG
Agent:
SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office Singapore 903031, SG
Priority Data:
10201509979S04.12.2015SG
Title (EN) CLINICAL CORRELATES OF IMMUNOTHERAPY EFFICACY
(FR) CORRÉLATS CLINIQUES D'EFFICACITÉ D'IMMUNOTHÉRAPIE
Abstract:
(EN) A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT, wherein the disease is preferably a disease caused or exacerbated by infection with Epstein-Barr virus (EBV), such as EBV-positive nasopharyngeal carcinoma (NPC). Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT, preferably EBV-positive NPC.
(FR) L'invention concerne un procédé permettant de prédire si un patient aura une survie à long terme lors du traitement d'une maladie par transfert adoptif de cellules (ACT), lequel procédé consistant : (i) à analyser un échantillon sanguin obtenu à partir du patient en ce qui concerne un ou plusieurs marqueurs de pronostic de survie à long terme lors du traitement d'une maladie par ACT; et (ii) sur la base de l'analyse de l'étape (i), à prédire si le patient a une survie à long terme lors du traitement de la maladie par ACT, la maladie étant de préférence une maladie provoquée ou exacerbée par une infection par le virus Epstein-Barr (EBV), telle que le carcinome nasopharyngé (NPC) EBV-positif. L'invention concerne également des procédés permettant de traiter un patient par ACT, des procédés permettant de sélectionner un patient pour le traitement par ACT et des procédés permettant de sélectionner un patient pour le traitement d'une maladie par ACT, de préférence le NPC EBV-positif.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20170312355SG11201804683RMYPI 2018702142EP3384052KR1020180099706ID2018/11501
IN201817023247CN108884497