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1. (WO2017094897) ANTI-IL-17 APTAMER HAVING IMPROVED RETENTION IN BLOOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/094897 International Application No.: PCT/JP2016/085948
Publication Date: 08.06.2017 International Filing Date: 02.12.2016
IPC:
C12N 15/115 (2010.01) ,A61K 31/7088 (2006.01) ,A61K 48/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 31/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/06 (2006.01) ,A61P 37/08 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
115
Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
08
Antiallergic agents
Applicants:
全薬工業株式会社 ZENYAKU KOGYO CO., LTD. [JP/JP]; 東京都文京区大塚五丁目6番15号 6-15, Otsuka 5-chome, Bunkyo-ku, Tokyo 1128650, JP
Inventors:
春田 和彦 HARUTA, Kazuhiko; JP
山▲崎▼ 宏亮 YAMAZAKI, Hiroaki; JP
Agent:
高島 一 TAKASHIMA, Hajime; JP
Priority Data:
2015-23749104.12.2015JP
Title (EN) ANTI-IL-17 APTAMER HAVING IMPROVED RETENTION IN BLOOD
(FR) APTAMÈRE ANTI-IL-17 PRÉSENTANT UNE MEILLEURE RÉTENTION DANS LE SANG
(JA) 血中滞留性を改善した抗IL-17アプタマー
Abstract:
(EN) The present invention provides an anti-IL-17 aptamer having improved in-vivo stability, said aptamer comprising a compound represented by formula (I) (wherein the symbols are as defined in the description) or a pharmaceutically acceptable salt thereof, and a solvate or hydrate.
(FR) La présente invention concerne un aptamère anti-IL-17 présentant une meilleure stabilité in vivo, ledit aptamère comprenant un composé représenté par la formule (I) (où les symboles sont tels que définis dans la description) ou un sel pharmaceutiquement acceptable de ce dernier, ou un solvate ou hydrate.
(JA) 本発明は、下記式(I):(各記号は明細書に定義される通りである。) で表される化合物又はその製薬学的に許容される塩、溶媒和物若しくは水和物からなる、生体内での安定性が改善された抗IL-17アプタマーを提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
AU2016364431CN108368509EP3385383