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1. (WO2017094793) VACCINE ANTIGEN WITH INCREASED IMMUNOGENICITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/094793 International Application No.: PCT/JP2016/085606
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
C07K 19/00 (2006.01) ,A01H 5/00 (2006.01) ,A23K 20/195 (2016.01) ,A61K 36/28 (2006.01) ,A61K 39/00 (2006.01) ,A61P 37/04 (2006.01) ,C07K 14/245 (2006.01) ,C07K 14/28 (2006.01) ,C07K 14/405 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
H
NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
5
Flowering plants, i.e. angiosperms
[IPC code unknown for A23K 20/195]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
24
from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245
Escherichia (G)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
28
from Vibrionaceae (F)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
405
from algae
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
出光興産株式会社 IDEMITSU KOSAN CO., LTD. [JP/JP]; 東京都千代田区丸の内三丁目1番1号 1-1, Marunouchi 3-chome, Chiyoda-ku, Tokyo 1008321, JP
Inventors:
澤田 和敏 SAWADA, Kazutoshi; JP
松井 健史 MATSUI, Takeshi; JP
Agent:
川口 嘉之 KAWAGUCHI, Yoshiyuki; JP
佐貫 伸一 SANUKI, Shinichi; JP
Priority Data:
2015-23371430.11.2015JP
2016-02309009.02.2016JP
Title (EN) VACCINE ANTIGEN WITH INCREASED IMMUNOGENICITY
(FR) ANTIGÈNE VACCINAL À IMMUNOGÉNICITÉ ACCRUE
(JA) 免疫原性が増強されたワクチン抗原
Abstract:
(EN) Immunogenicity of an antigen peptide is increased by administering, to an animal, a transfectant that has been transfected with a fusion protein or a gene that codes the same, said fusion protein including an antigen peptide and an adjuvant protein, wherein the adjuvant protein includes two or more proteins selected from the group consisting of the B subunit (Stx2eB) of Shiga toxin 2e, the B subunit (LTB) of a heat-labile Escherichia coli toxin, and the B subunit (CTB) of a cholera toxin.
(FR) L'immunogénicité d'un peptide antigénique est augmentée par administration, à un animal, d'un transfectant qui a été transfecté avec une protéine de fusion ou un gène qui code pour celle-ci, ladite protéine de fusion comprenant un peptide antigénique et un adjuvant protéique, la protéine adjuvante comprenant au moins deux protéines sélectionnées dans le groupe constitué de la sous-unité B (Stx2eB) de la toxine Shiga 2e, la sous-unité B (LTB) d'une toxine thermolabile d'Escherichia coli, et la sous-unité B (CTB) d'une toxine du choléra.
(JA) 抗原ペプチドとアジュバントタンパク質を含む融合タンパク質であって、前記アジュバントタンパク質は志賀毒素2eのBサブユニット(Stx2eB)、大腸菌易熱性毒素のBサブユニット(LTB)及びコレラ毒素のBサブユニット(CTB)から選択される2以上のタンパク質を含む、融合タンパク質、またはそれをコードする遺伝子で形質転換された形質転換体を動物に投与することで抗原ペプチドの免疫原性を高める。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
CN108290961KR1020180083904US20180265553EP3385286