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1. (WO2017094792) TARGETED SHELL FOR USE IN DRUG DELIVERY SYSTEM UTILIZING CARBOSILANE DENDRIMER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/094792 International Application No.: PCT/JP2016/085604
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
Chapter 2 Demand Filed: 29.09.2017
IPC:
A61K 47/24 (2006.01) ,A61K 47/42 (2017.01) ,A61K 49/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01) ,C07K 17/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
Applicants:
株式会社Quarrymen&Co. QUARRYMEN&CO. INC. [JP/JP]; 東京都世田谷区成城6-14-23 14-23, Seijo 6-chome, Setagaya-ku, Tokyo 1570066, JP
国立大学法人埼玉大学 SAITAMA UNIVERSITY [JP/JP]; 埼玉県さいたま市桜区下大久保255 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 3388570, JP
Inventors:
鈴木 美穂 SUZUKI, Miho; JP
幡野 健 HATANO, Ken; JP
吉田 彰次郎 YOSHIDA, Shojiro; JP
山下 靖弘 YAMASHITA, Yasuhiro; JP
Agent:
特許業務法人綾船国際特許事務所 AYAFUNE INTERNATIONAL PATENTS & TRADEMARKS PATENT PROFESSIONAL CORPORATION; 東京都中央区京橋1丁目19番4号TAF京橋ビル5F TAF Kyobashi Bldg. 5th Floor, 19-4, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031, JP
Priority Data:
2016-10670027.05.2016JP
PCT/JP2015/08362230.11.2015JP
Title (EN) TARGETED SHELL FOR USE IN DRUG DELIVERY SYSTEM UTILIZING CARBOSILANE DENDRIMER
(FR) ENVELOPPE CIBLÉE POUR UTILISATION DANS UN SYSTÈME D’ADMINISTRATION DE MÉDICAMENT UTILISANT UN DENDRIMÈRE DE CARBOSILANE
(JA) カルボシランデンドリマーを用いた薬物送達システム用標的型シェル
Abstract:
(EN) The present invention relates to a targeted shell for a drug delivery system. The purpose of the present invention is to provide a targeted shell for use in a drug delivery system. Utilizing the reactivity of a thiol and an alkyl halide, the targeted shell incorporates a silole-containing carbosilane dendrimer and a marker protein (such as a green fluorescent protein) containing a target-recognizing site, and is able to encapsulate a biopolymer or other molecule, and to selectively deliver the biopolymer or the like into target cells.
(FR) La présente invention concerne une enveloppe ciblée pour un système d’administration de médicament. L’objectif de la présente invention est de fournir une enveloppe ciblée pour utilisation dans un système d’administration de médicament. En utilisant la réactivité d'un thiol et d’un halogénure d'alkyle, l’enveloppe ciblée incorpore un dendrimère de carbosilane contenant un silole et une protéine marqueuse (telle qu’une protéine fluorescente verte) contenant un site de reconnaissance de cible, et est capable d’encapsuler un biopolymère ou une autre molécule, et d’administrer sélectivement le biopolymère ou similaire dans des cellules cibles.
(JA) 本発明は、ドラッグデリバリーシステム用標的型シェルに関する。本発明は、チオールとハロゲン化アルキルの反応性を利用して、シロール含有カルボシランデンドリマーと、標的認識部位を含む標識タンパク質(例えば、緑色蛍光タンパク質)とを含み、生体高分子その他の分子を内包することができ、標的細胞中に前記生体高分子等を選択的に送達することができる、ドラッグデリバリーシステム用標的型シェルを提供することを目的とする。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP3384934CN108697802