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1. (WO2017094745) COMPOSITION INCLUDING NUCLEIC ACID FOR ENTERAL ADMINISTRATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/094745 International Application No.: PCT/JP2016/085474
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
A61K 38/00 (2006.01) ,A23L 33/15 (2016.01) ,A61K 31/713 (2006.01) ,A61K 47/28 (2006.01) ,A61K 47/50 (2017.01) ,A61P 1/16 (2006.01) ,C07K 19/00 (2006.01) ,C12N 15/09 (2006.01) ,C12N 15/113 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
[IPC code unknown for A23L 33/15]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
28
Steroids
[IPC code unknown for A61K 47/50]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
国立大学法人大阪大学 OSAKA UNIVERSITY [JP/JP]; 大阪府吹田市山田丘1番1号 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP
国立大学法人東京医科歯科大学 NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY [JP/JP]; 東京都文京区湯島一丁目5番45号 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo 1138510, JP
Inventors:
八木 清仁 YAGI, kiyohito; JP
近藤 昌夫 KONDOH, Masuo; JP
渡利 彰浩 WATARI, Akihiro; JP
村上 正裕 MURAKAMI, Masahiro; JP
永浜 政博 NAGAHAMA, Masahiro; JP
横田 隆徳 YOKOTA, Takanori; JP
永田 哲也 NAGATA, Tetsuya; JP
渡辺 知恵 WATANABE, Chie; JP
Agent:
田中 順也 TANAKA, Junya; JP
水谷 馨也 MIZUTANI, Keiya; JP
Priority Data:
2015-23470001.12.2015JP
Title (EN) COMPOSITION INCLUDING NUCLEIC ACID FOR ENTERAL ADMINISTRATION
(FR) COMPOSITION INCLUANT UN ACIDE NUCLÉIQUE POUR L'ADMINISTRATION PAR VOIE ENTÉRALE
(JA) 核酸を含む経腸投与用組成物
Abstract:
(EN) The purpose of the present invention is to provide a novel composition for enteral administration, by which a nucleic acid is efficiently absorbed through an inter-epithelial-cell gap path in the digestive tract. According to the present invention, by using a tight junction-binding peptide in combination with a nucleic acid to which a fat-soluble substance is bound, the nucleic-acid absorbability through an inter-epithelial-cell gap in the digestive tract can be remarkably improved.
(FR) Le but de la présente invention est de fournir une nouvelle composition d'administration entérale, par laquelle un acide nucléique est efficacement absorbé à travers un chemin d'espace cellulaire interépithélial dans le tractus digestif. Selon la présente invention, en utilisant un peptide de liaison à jonction étroite en combinaison avec un acide nucléique auquel une substance soluble dans les matières grasses est liée, la capacité d'absorption d'acide nucléique à travers un espace cellulaire interépithélial dans le tractus digestif peut être remarquablement améliorée.
(JA) 本発明の目的は、核酸が消化管の上皮細胞間隙経路を介して効率的に吸収される新たな経腸投与用組成物を提供することである。 タイトジャンクション結合性ペプチドと脂溶性物質を結合させた核酸とを併用することによって、消化管の上皮細胞間隙を介する核酸の吸収性を格段に向上させ得る。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)