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1. (WO2017093947) ANTIBODY CYTOKINE ENGRAFTED COMPOSITIONS AND METHODS OF USE FOR IMMUNOREGULATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093947 International Application No.: PCT/IB2016/057283
Publication Date: 08.06.2017 International Filing Date: 01.12.2016
IPC:
C07K 14/54 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
Applicants:
NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel, CH
Inventors:
DIDONATO, Michael; US
KNUTH, Mark; US
MEEUSEN, Shelly; US
SPRAGGON, Glen; US
TRAUGER, John; US
GEIERSTANGER, Bernhard Hubert; US
SIMPSON, Carolina Nicole; US
JUNT, Tobias; CH
Agent:
NOVARTIS AG; Lichtstrasse 35 4056 Basel, CH
Priority Data:
62/263,00804.12.2015US
Title (EN) ANTIBODY CYTOKINE ENGRAFTED COMPOSITIONS AND METHODS OF USE FOR IMMUNOREGULATION
(FR) COMPOSITIONS À GREFFE DE CYTOKINE-ANTICORPS ET PROCÉDÉS D'UTILISATION POUR L'IMMUNORÉGULATION
Abstract:
(EN) The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro- inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.
(FR) La présente invention concerne des protéines à greffe de cytokine-anticorps qui se lient à une signalisation intercellulaire et la stimulent par l'intermédiaire du récepteur de l'interleukine 10. Les protéines à greffe de cytokine-anticorps peuvent être utilisées pour renforcer les réponses des cellules anti-inflammatoires, et pour réduire les effets pro-inflammatoires dans le traitement, l'amélioration et la prophylaxie de troubles de nature immunitaire. L'invention concerne également des polynucléotides et des vecteurs qui codent pour des protéines à greffe de cytokine-anticorps et des cellules hôtes aptes à produire des protéines à greffe de cytokine-anticorps, ainsi que des procédés de combinaison de protéines à greffe de cytokine-anticorps avec d'autres agents thérapeutiques dans le traitement d’un trouble de nature immunitaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UY0001037003AU2016362777CA3006477SG11201804259UCU2018000047MYPI 2018701908
IL259529KR1020180081622EP3383891CN108602870ID2018/11692MX2018006778
BR112018010937EA201891341PH1/2018/501160