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1. (WO2017093938) TETRAHYDROISOQUINOLINE DERIVATIVES



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/IB2016/057270 PR66005
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
01 December 2016 04 December 2015
Applicant
VIIV HEALTHCARE UK LIMITED
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 405/14 (2006.01)i; A61P 31/18 (2006.01)i; C07D 217/04 (2006.01)i; C07D 217/06 (2006.01)i; C07D 217/08 (2006.01)i; C07D 217/24 (2006.01)i; C07D 401/06 (2006.01)i; C07D 405/04 (2006.01)i; C07D 413/04 (2006.01)i; A61K 31/472 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, CHEM ABS Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2014119636 A1 (SHIONOGI & CO [JP]) 07 August 2014 (2014-08-07)
1-18
Y
abstract
1-13,16-18
X,P
& EP 2952503  A1  (SHIONOGI & CO [JP]) 09 December 2015 (2015-12-09)
1-18
Y,P
compounds of the examples, e.g. compound 7 on page 118, compound 33 on page 142, compound 4 on page 175, compound 82 on page 185, 5th compound on page 188;paragraphs [0001], [0024] - [0026], [0047], [0172], [0173]; claims 1,44-47; tables A-1 - A-9
1-13,16-18
(2)
Y
WO 2004096774 A1 (GLAXO GROUP LTD [GB]; BRAVI GIANPAOLO [GB]; CORFIELD JOHN ANDREW [GB];) 11 November 2004 (2004-11-11)
1-13,16-18
example compounds;page 1, paragraph 1; claims 1,14-17
(3)
X
REGISTRY18 June 2015 (2015-06-18), Database accession no. 1783707-94-7
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002766551
1-4,7,10
compound cas rn: 1783707-94-7
(4)
X
REGISTRY23 December 2013 (2013-12-23), Database accession no. 1501813-10-0
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002766552
1-4,7,10
compound cas rn: 1501813-10-0
(5)
X
REGISTRY31 December 2013 (2013-12-31), Database accession no. 1507478-99-0
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002766553
1-4,7,10
compound cas rn: 1507478-99-0
(6)
X
REGISTRY30 May 2010 (2010-05-30), Database accession no. 1226062-01-6
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002766554
1-4
compound cas rn: 1226062-01-6
(7)
X
REGISTRY30 May 2010 (2010-05-30), Database accession no. 1226243-44-2
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002766555
1-4
compound cas rn: 1226243-44-2
(8)
X
Vasiliu, George; Greff, Cristea, "Synthesis of derivatives of 1,2,3,4-tetrahydronaphthalene-6-acetic acid with spasmolytic activity", CAPLUS1965, Database accession no. 1967:490565
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002766556
1-4,16
compounds cas rn's: 16241-93-3 and 16241-92-2
(9)
X
WILKINS REEVE ET AL, "Reaction of chloral with naphthalene, and the synthesis of [alpha]-methoxynaphthylacetic acids from naphthyl(trichloromethyl)carbinols", CANADIAN JOURNAL OF CHEMISTRY,Vol. 46, No. 13, 01 July 1968 (1968-07-01), page 2233-2238,
XP055340482
1-4,9
page 2237, column 2, paragraphs 3,4
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2014119636 A1
07 August 2014
EP 2952503 A1
JP WO2014119636 A1
TW 201441197 A
US 2015361093 A1
WO 2014119636 A1
09 December 2015
26 January 2017
01 November 2014
17 December 2015
07 August 2014
WO 2004096774 A1
11 November 2004
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
31 January 2017
Date of mailing of the international search report:
13 February 2017
Authorized officer:
Guspanová, Jana
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