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1. (WO2017093897) AROMATIC-CATIONIC PEPTIDES CONJUGATED TO ANTIOXIDANTS AND THEIR USE IN TREATING COMPLEX REGIONAL PAIN SYNDROME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093897 International Application No.: PCT/IB2016/057191
Publication Date: 08.06.2017 International Filing Date: 29.11.2016
IPC:
A61K 47/55 (2017.01) ,A61K 47/66 (2017.01) ,A61P 25/02 (2006.01) ,C07K 5/06 (2006.01) ,C07K 5/08 (2006.01) ,C07K 5/10 (2006.01)
[IPC code unknown for A61K 47/55][IPC code unknown for A61K 47/66]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
02
for peripheral neuropathies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
Applicants:
SCHILLER, Peter [CA/CA]; CA
BEREZOWSKA, Irena [CA/CA]; CA
Inventors:
SCHILLER, Peter; CA
BEREZOWSKA, Irena; CA
Priority Data:
62/261,18030.11.2015US
Title (EN) AROMATIC-CATIONIC PEPTIDES CONJUGATED TO ANTIOXIDANTS AND THEIR USE IN TREATING COMPLEX REGIONAL PAIN SYNDROME
(FR) PEPTIDES AROMATIQUES-CATIONIQUES CONJUGUÉS À DES ANTIOXYDANTS ET LEUR UTILISATION DANS LE TRAITEMENT D'UN SYNDROME DOULOUREUX RÉGIONAL COMPLEXE
Abstract:
(EN) Compositions comprising an antioxidant directed or indirectly conjugated to an aromatic-cationic peptide are provide. Said antioxidants are selected from TEMPO, Tro, PBN, AHDP, DBHP, Caf and Hem and may be conjugated to the aromatic-cationic peptide directly or indirectly via a linker to the N-terminus, C-terminus or a side chain of an amino acid residue of the aromatic-cationic peptide. In some embodiments, the aromatic-cationic peptide is 2',6'-Dmt-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2 or D-Arg-2',6'-Dmt-Lys-Phe-NH2. These conjugates have increased antioxidant activity as compared to the unconjugated aromatic-cationic peptide and have utility in treating complex regional pain syndrome.
(FR) La présente invention concerne des compositions comprenant un antioxydant conjugué directement ou indirectement à un peptide aromatique-cationique. Lesdits antioxydants sont choisis parmi TEMPO, Tro, PBN, AHDP, DBHP, Caf et Hem et peuvent être conjugués au peptide cationique-aromatique directement ou indirectement par l'intermédiaire d'un lieur qui se lie à l'extrémité N-terminale, à l'extrémité C-terminale ou à une chaîne latérale d'un résidu d'acide aminé du peptide aromatique-cationique. Dans certains modes de réalisation, le peptide aromatique-cationique est le 2',6'-Dmt-D-Arg-Phe-Lys-NH2, le Phe-D-Arg-Phe-Lys-NH2 ou le D-Arg-2',6'-Dmt-Lys-Phe-NH2. Ces conjugués ont une activité antioxydante accrue par comparaison avec le peptide aromatique-cationique non conjugué et sont utiles dans le traitement d'un syndrome douloureux régional complexe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3006698