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1. (WO2017093649) MUTATED HEV POLYPEPTIDES AND THE USE THEREOF FOR ASSAYING ANTI-HEV ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093649 International Application No.: PCT/FR2016/053127
Publication Date: 08.06.2017 International Filing Date: 29.11.2016
IPC:
C07K 14/08 (2006.01) ,G01N 33/576 (2006.01) ,C07K 14/005 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
576
for hepatitis
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
Applicants:
BIOMÉRIEUX [FR/FR]; 69280 Marcy l'Étoile, FR
Inventors:
ATAMAN-ONAL, Yasemin; FR
DANIEL, Soizic; FR
GOUTAGNY, Nadège; FR
LUCIANI, Françoise; FR
Agent:
BITAUD, Valérie; FR
Priority Data:
156159630.11.2015FR
Title (EN) MUTATED HEV POLYPEPTIDES AND THE USE THEREOF FOR ASSAYING ANTI-HEV ANTIBODIES
(FR) POLYPEPTIDES MUTÉS DE HEV ET LEUR UTILISATION POUR LE DOSAGE D'ANTICORPS ANTI-HEV
Abstract:
(EN) The present invention relates to polypeptides of the ORF2 protein of the hepatitis E virus including at least the amino acid sequence 394-660, numbered in relation to an ORF2 protein of 660 amino acids, in which three cysteines at positions 627, 630 and 638 have been mutated or, for an ORF2 protein of different length, at least the amino acid sequence corresponding to amino acids 394-660 of the ORF2 protein of 660 amino acids, in which the three cysteines located at the three positions corresponding to positions 627, 630 and 638 of the ORF2 protein of 660 amino acids have been mutated. The invention also relates to methods for determining the presence of the humoral response or the number of antibodies directed against the ORF2 protein using these polypeptides, as well as the use thereof in the context of infection with the hepatitis E virus. No figure
(FR) La présente invention concerne des polypeptides de la protéine p-ORF2 du virus de l'hépatite E comprenant au moins la séquence d'acides aminés 394-660, numérotés par rapport à une protéine p-ORF2 de 660 acides aminés, dans laquelle les trois cystéines en positions 627, 630 et 638 ont été mutées ou, pour une protéine p-ORF2 de longueur différente, au moins la séquence d'acides aminés correspondant aux acides aminés 394-660 de la protéine p-ORF2 de 660 acides aminés, dans laquelle les trois cystéines situées aux trois positions correspondant aux positions 627, 630 et 638 de la protéine p-ORF2 de 660 acides aminés ont été mutées. Elle concerne également des procédés de détermination de la présence de la réponse humorale ou du taux d'anticorps dirigés contre la protéine p-ORF2 utilisant ces polypeptides, ainsi que leur utilisation dans le cadre d'un contexte d'infection au virus de l'hépatite E. Pas de figure
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
FR3044312KR1020180083941CN108473540EP3383887US20180328929IN201817023839
BR112018009851