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1. (WO2017093593) NEW FAMILY OF COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, AND USES THEREOF IN THE TREATMENT AND/OR PROPHYLAXIS OF DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093593 International Application No.: PCT/ES2016/070859
Publication Date: 08.06.2017 International Filing Date: 02.12.2016
Chapter 2 Demand Filed: 27.09.2017
IPC:
C07D 403/14 (2006.01) ,C07D 403/04 (2006.01) ,A61K 31/4192 (2006.01) ,A61K 31/4025 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4192
1,2,3-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
Applicants:
UNIVERSIDAD DE BURGOS [ES/ES]; C/ Hospital del Rey s/n 09001 Burgos, ES
UNIVERSITAT DE BARCELONA [ES/ES]; Baldiri Reixac, 4 08028 Barcelona, ES
Inventors:
QUESADA PATO, Roberto; ES
HERNANDO SANTA CRUZ, Elsa; ES
PÉREZ TOMÁS, Ricardo Enrique; ES
SOTO CERRATO, Vanessa; ES
ZEGARRA, Olga L.A.; ES
Agent:
ILLESCAS TABOADA, Manuel; ES
Priority Data:
P20153174902.12.2015ES
Title (EN) NEW FAMILY OF COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, AND USES THEREOF IN THE TREATMENT AND/OR PROPHYLAXIS OF DISEASES
(ES) UNA NUEVA FAMILIA DE COMPUESTOS, PROCEDIMIENTO DE OBTENCIÓN DE LOS MISMOS Y SUS USOS EN EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES
(FR) NOUVELLE FAMILLE DE COMPOSÉS, PROCÉDÉ D'OBTENTION DE CEUX-CI ET LEURS UTILISATIONS DANS LE TRAITEMENT ET/OU LA PROPHYLAXIE DE MALADIES
Abstract:
(EN) The invention relates to compounds of formula (I) or addition salts and/or pharmaceutically acceptable solvates thereof, and the pharmaceutical compositions containing same. The invention also relates to a method for producing said compounds of formula (I) or addition salts and/or pharmaceutically acceptable solvates thereof. Finally the invention relates to the use of said compounds of formula (I) or addition salts and/or pharmaceutically acceptable solvates thereof, and of the pharmaceutical compositions containing same for the preparation of a drug. In particular, drugs intended for the treatment and/or prophylaxis of diseases derived from abnormal anion transport at a cellular level and, more specifically, those intended for the treatment and/or prophylaxis of cystic fibrosis.
(ES) La presente invención describe compuestos de fórmula (I) o sales de adición y/o solvatos farmacéuticamente aceptables de los mismos, y las composiciones farmacéuticas que los contienen. Así mismo, describe un proceso de obtención de dichos compuestos de fórmula (I) o sales de adición y/o solvatos farmacéuticamente aceptables de los mismos. Por último la presente invención trata del uso de dichos compuestos de fórmula (I) o sales de adición y/o solvatos farmacéuticamente aceptables de los mismos y de las composiciones farmacéuticas que los contienen, para preparar un medicamento. Especialmente medicamentos destinados al tratamiento y/o profilaxis de enfermedades derivadas del transporte anómalo de aniones a nivel celular y, más en concreto, a los destinados al tratamiento y/o profilaxis de la fibrosis quística.
(FR) La présente invention concerne des composés de formule (I) ou des sels d'addition et/ou solvates pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques les comprenant. L'invention concerne également un procédé d'obtention desdits composés de formule (I) ou des sels d'addition et/ou solvates pharmaceutiquement acceptables de ceux-ci. L'invention concerne en outre l'utilisation desdits composés de formule (I) ou sels d'addition et/ou solvates pharmaceutiquement acceptables de ceux-ci et des compositions pharmaceutiques les contenant, pour préparer un médicament. En particulier, les médicaments sont destinés au traitement et/ou à la prophylaxie de maladies dérivées du transport anormal d'anions au niveau cellulaire et, plus concrètement, sont destinés au traitement et/ou à la prophylaxie de la fibrose kystique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)