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1. (WO2017093569) MEANS AND METHODS FOR TREATING AND DIAGNOSING FIBROSIS OR FIBROSIS-ASSOCIATED DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093569 International Application No.: PCT/EP2016/079777
Publication Date: 08.06.2017 International Filing Date: 05.12.2016
IPC:
A61K 38/39 (2006.01) ,C07K 14/78 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
39
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
Applicants:
DEUTSCHES KREBSFORSCHUNGSZENTRUM [DE/DE]; Im Neuenheimer Feld 280 69120 Heidelberg, DE
Inventors:
ABDOLLAHI, Amir; DE
JAVAHERIAN, Kashi; US
DEBUS, Jürgen; DE
ZHOU, Cheng; DE
Agent:
HERZOG FIESSER & PARTNER PATENTANWÄLTE PARTG MBB; Dudenstraße 46 68167 Mannheim, DE
Priority Data:
15197746.903.12.2015EP
Title (EN) MEANS AND METHODS FOR TREATING AND DIAGNOSING FIBROSIS OR FIBROSIS-ASSOCIATED DISEASES
(FR) MOYENS ET MÉTHODES DE TRAITEMENT ET DE DIAGNOSTIC DE LA FIBROSE ET DE MALADIES ASSOCIÉES À UNE FIBROSE
Abstract:
(EN) The present invention is concerned with a protein oligomer comprising (i) at least two NC- monomers of collagen 18 or (ii) at least two endostatin domains of collagen 18 or (iii) at least two N-terminal peptides of the collagen 18 endostatin domain, for use in treating, ameliorating or preventing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease. The invention further relates to the mentioned protein oligomer for use for detecting and/or diagnosing fibrosis or a fibrosis-associated disease,a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease.
(FR) La présente invention concerne une protéine oligomérique comprenant (i) au moins deux monomères -NC du collagène 18 ou (ii) au moins deux domaines endostatine du collagène 18 ou (iii) au moins deux peptides N-terminaux du domaine endostatine du collagène 18, utilisé pour traiter, améliorer ou prévenir la fibrose ou une maladie associée à une fibrose, une maladie liée au facteur de croissance endothéliale vasculaire (VEGF) ou une maladie liée aux métalloprotéases matricielles (MMP). L'invention concerne également l'utilisation de la protéine oligomérique de l'invention pour détecter et/ou diagnostiquer une fibrose ou une maladie associée à une fibrose, une maladie liée au facteur de croissance endothéliale vasculaire (VEGF) ou une maladie liée aux métalloprotéases matricielles (MMP).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3007147EP3383424CN109069591