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1. (WO2017093448) ANTI-DR5 ANTIBODIES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093448 International Application No.: PCT/EP2016/079518
Publication Date: 08.06.2017 International Filing Date: 01.12.2016
IPC:
C07K 16/28 (2006.01) ,C07K 16/30 (2006.01) ,C07K 16/46 (2006.01) ,A61K 39/395 (2006.01) ,C12N 15/13 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
Applicants:
GENMAB B.V. [NL/NL]; Uppsalalaan 15 3584 CT Utrecht, NL
Inventors:
OVERDIJK, Marije; NL
STRUMANE, Kristin; NL
RADEMAKER, Rik; NL
BREIJ, Esther; NL
SCHUURMAN, Janine; NL
PARREN, Paul; NL
Agent:
GENMAB A/S; Kalvebod Brygge 43 1560 Copenhagen V, DK
Priority Data:
PA 2015 0077101.12.2015DK
PA 2015 0078707.12.2015DK
PA 2015 0078807.12.2015DK
PA 2016 0070110.11.2016DK
PA 2016 0070210.11.2016DK
Title (EN) ANTI-DR5 ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-DR5 ET PROCÉDÉS D'UTILISATION DE CEUX-CI
Abstract:
(EN) The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DR5 antigen. The invention relates in particular to DR5-specific antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DR5 signalling, apoptosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DR5. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.
(FR) La présente invention concerne des molécules d'anticorps monospécifiques ou bispécifiques qui se lient spécifiquement à l'antigène DR5 humain. L'invention concerne en particulier des molécules d'anticorps spécifiques pour DR5 de l'isotype IgG1 comportant une mutation dans la région Fc qui augmente l'agrégation de molécules IgG après la liaison d'un antigène de surface cellulaire conduisant à l'induction d'une signalisation DR5, l'apoptose et la mort cellulaire. L'invention concerne en outre une combinaison de molécules d'anticorps se liant à différents épitopes sur DR5. L'invention concerne en outre des compositions pharmaceutiques contenant ces molécules et le traitement du cancer au moyen de ces compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201807311CA3007033AU2016363770SG11201803956UIN201847023892IL259713
EP3383906KR1020180098567BR112018011100CN109476737US20190144554