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1. (WO2017093447) ANTI-DEATH RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093447 International Application No.: PCT/EP2016/079517
Publication Date: 08.06.2017 International Filing Date: 01.12.2016
IPC:
C07K 16/28 (2006.01) ,C07K 16/30 (2006.01) ,C07K 16/46 (2006.01) ,A61K 39/395 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
GENMAB B.V. [NL/NL]; Uppsalalaan 15 3584 CT Utrecht, NL
Inventors:
BEURSKENS, Frank; NL
OVERDIJK, Marije; NL
DE JONG, Rob; NL
SATIJN, David; NL
STRUMANE, Kristin; NL
SCHUURMAN, Janine; NL
PARREN, Paul; NL
Agent:
GENMAB A/S; Kalvebod Brygge 43 1560 Copenhagen V, DK
Priority Data:
PA 2015 0077101.12.2015DK
PA 2015 0078707.12.2015DK
PA 2015 0078807.12.2015DK
PA 2016 0070110.11.2016DK
PA 2016 0070210.11.2016DK
Title (EN) ANTI-DEATH RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-RÉCEPTEUR DE MORT ET PROCÉDÉS D'UTILISATION ASSOCIÉS
Abstract:
(EN) The present invention relates to monospecific or bispecific antibody molecules that specifically bind antigens of Death Receptors, which are members of the tumor necrosis factor (TNF) receptor Superfamily (TNFR-SF) with an intracellular death domain. The invention relates in particular to antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after target binding. The invention further relates to a combination of antibody molecules binding different epitopes on one or more specific Death Receptors. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.
(FR) La présente invention concerne des molécules d'anticorps monospécifiques ou bispécifiques qui se lient spécifiquement à des antigènes des récepteurs de mort, qui sont des membres de la superfamille de récepteurs du facteur de nécrose tumorale (TNF) (TNFR-SF) avec un domaine de mort intracellulaire. L'invention concerne en particulier des molécules d'anticorps de l'isotype IgG1 ayant une mutation dans la région Fc qui améliore l'agrégation de molécules d'IgG après liaison à la cible. L'invention concerne également une combinaison de molécules d'anticorps se liant à différents épitopes sur un ou plusieurs récepteurs de mort spécifiques. L'invention concerne également des compositions pharmaceutiques contenant ces molécules et le traitement du cancer à l'aide de ces compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3007031EP3383905CN108884158BR112018011058US20190202926