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1. (WO2017093400) METHOD FOR DETERMINING CELL CLONALITY



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2016/079427 P 15/116 WO/PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
01 December 2016 03 December 2015
Applicant
ARES TRADING S.A.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12Q 1/68 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12Q
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
SUFFICOOL KARI E ET AL, "T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.", August 2015 (2015-08), JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY AUG 2015, VOL. 73, NR. 2, PAGE(S) 228 - 36.E2,
XP002766636
1-19
figure 2
(2)
A
BLECK G T, "An Alternative Method for the Rapid Generation of Stable, High-Expressing Mammalian Cell Lines", Vol. 1, No. 7, 01 September 2005 (2005-09-01), BioProcessing Journal
Retrieved from the Internet:
URL:http://www.gala.com/pdf/bioprocessingj.pdf
XP002761142
[retrieved on  2016-09-02]
1-19
the whole document
(3)
A
BOYD S D ET AL, "Measurement and clinical monitoring of human lymphocyte clonality by massively parallel V-D-J pyrosequencing", SCIENCE TRANSLATIONAL MEDICINE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC,Vol. 1, No. 12, 23 December 2009 (2009-12-23), page 1-8,
XP003031087
1-19
the whole document
(4)
A
WO 2012083069 A2 (UNIV LELAND STANFORD JUNIOR [US]; FIRE ANDREW [US]; BOYD SCOTT D [US];) 21 June 2012 (2012-06-21)
1-19
the whole document
(5)
A
US 2015038337 A1 (LIU JUNJIAN [US] ET AL) 05 February 2015 (2015-02-05)
1-19
the whole document
(6)
A
KR 20140096988 A (MERCK SERONO SA [CH]) 06 August 2014 (2014-08-06)
1-19
(7)
A
US 2013130311 A1 (SHAPIRO EHUD Y [IL] ET AL) 23 May 2013 (2013-05-23)
1-19
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2012083069 A2
21 June 2012
US 2012220466 A1
US 2014235477 A1
WO 2012083069 A2
30 August 2012
21 August 2014
21 June 2012
US 2015038337 A1
05 February 2015
US 2015038337 A1
WO 2015017496 A1
05 February 2015
05 February 2015
KR 20140096988 A
06 August 2014
NONE
US 2013130311 A1
23 May 2013
US 2013130311 A1
WO 2012014208 A2
23 May 2013
02 February 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
01 February 2017
Date of mailing of the international search report:
15 February 2017
Authorized officer:
Seroz, Thierry
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