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1. (WO2017093370) T-CELL SPECIFIC GENOME EDITING
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093370 International Application No.: PCT/EP2016/079370
Publication Date: 08.06.2017 International Filing Date: 01.12.2016
IPC:
C12N 15/85 (2006.01) ,A01K 67/027 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
Applicants:
TECHNISCHE UNIVERSITÄT MÜNCHEN [DE/DE]; Arcisstraße 21 80333 München, DE
Inventors:
BEIL-WAGNER, Jane; CH
BUCH, Thorsten; DE
Agent:
LEISSLER-GERSTL, Gabriele; DE
Priority Data:
15197843.403.12.2015EP
Title (EN) T-CELL SPECIFIC GENOME EDITING
(FR) ÉDITION GÉNOMIQUE SPÉCIFIQUE DES LYMPHOCYTES T
Abstract:
(EN) The present invention is concerned with the provision of a modified CRISPR/Cas9 system that can be used to directly edit genes in T cells. The modified CRISPR/Cas9 system of the present invention allows single-step direct analysis of gene function within Tcells lineage and circumvents the tedious gene targeting and crossing necessary for Cre/loxP-mediated conditional gene ablation.
(FR) La présente invention concerne un système CRISPR/Cas9 modifié qui peut être utilisé pour éditer directement des gènes dans les lymphocytes T. Le système CRISPR/Cas9 modifié selon la présente invention permet une analyse directe et en une seule étape de la fonction génique dans une lignée de lymphocytes T et élimine le ciblage génique fastidieux et le croisement nécessaire pour l'ablation génétique conditionnelle à médiation par Cre/loxP.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)