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1. (WO2017093300) 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/093300 International Application No.: PCT/EP2016/079251
Publication Date: 08.06.2017 International Filing Date: 30.11.2016
IPC:
C07D 417/14 (2006.01) ,A61K 31/501 (2006.01) ,A61K 31/53 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ASTRAZENECA AB [SE/SE]; SE-151 85 Södertälje, SE
CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building 407 St John Street London EC1V 4AD, GB
Inventors:
FINLAY, Maurice, Raymond, Verschoyle; GB
NISSINK, Johannes, Wilhelmus, Maria; GB
CHARLES, Mark, David; GB
WOOD, James, Matthew; GB
Agent:
COOK, Andrew; GB
Priority Data:
62/26078730.11.2015US
Title (EN) 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER
(FR) COMPOSÉS DE 1,3,4-THIADIAZOLE ET LEUR UTILISATION POUR TRAITER LE CANCER
Abstract:
(EN) A compound of Formula (I) or a pharmaceutically acceptable salt thereof, where: Q can be 5-methylpyridazin-3-yl, 5-chloropyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl; R can be hydrogen, fluoro, or methoxy; R1 can be hydrogen, methoxy, difluoromethoxy, or trifluoromethoxy; and R2 can be methyl or ethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.
(FR) L'invention concerne un composé de formule (I) : (I) ou son sel pharmaceutiquement acceptable, Q pouvant être 5-méthylpyridazin-3-yl, 5-chloropyridazin-3-yl, 6-méthylpyridazin-3-yl, ou 6-fluoropyridazin-3-yl; R pouvant être hydrogène, fluoro ou méthoxy; R1 pouvant être hydrogène, méthoxy, difluorométhoxy ou trifluorométhoxy; et R2 pouvant être méthyle ou éthyle. Le composé de formule (I) peut inhiber une glutaminase, par exemple la GLS1.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AO3665CA3005516AU2016363719SG11201803813UDOP2018000134IN201817012960
MYPI 2018702016KR1020180083412CN108349967EP3383871ID2018/11088BR112018010812
EA201891240PH1/2018/501132