Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2017092645) FULL HUMAN ANTIBODY AGAINST RESPIRATORY SYNCYTIAL VIRUS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/092645 International Application No.: PCT/CN2016/107658
Publication Date: 08.06.2017 International Filing Date: 29.11.2016
IPC:
C07K 16/00 (2006.01) ,A61K 39/395 (2006.01) ,C12N 15/63 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
天津昊免生物技术有限公司 ELITEIMMUNE INC. [CN/CN]; 中国天津市 开发区洞庭路220号国际生物医药联合研究院S1406 Room S1406, International Joint Academy of Biomedicine, No. 220, Dongting Road, TEDA Tianjin 300457, CN
Inventors:
赵雪莲 ZHAO, Xuelian; CN
刘国华 LIU, Guohua; CN
王全英 WANG, Quanying; CN
Agent:
北京布瑞知识产权代理有限公司 BRIGHTHEAD INTELLECTUAL PROPERTY AGENCY CO., LTD.; 中国北京市 朝阳区广顺北大街5号院内32号B228 B228, No. 32, Inside the No. 5 Yard, Guangshun North Street, Chaoyang District Beijing 100102, CN
Priority Data:
201510867051.930.11.2015CN
201611036424.923.11.2016CN
Title (EN) FULL HUMAN ANTIBODY AGAINST RESPIRATORY SYNCYTIAL VIRUS
(FR) ANTICORPS COMPLÈTEMENT HUMANISÉ CONTRE LE VIRUS RESPIRATOIRE SYNCYTIAL
(ZH) 一种抗呼吸道合胞病毒的全人源抗体
Abstract:
(EN) Disclosed are an antibody (preferably a full human antibody R66) against respiratory syncytial virus RSV, encoding nucleic acids thereof, a vector and a host cell comprising the same, and a preparation method therefor. Disclosed are also a use of the antibody (preferably a full human antibody R66) against RSV in the prevention and treatment of RSV-related diseases, and a use of the same in detecting RSV. The above antibody against RSV is preferably a full human monoclonal antibody. Compared with other animal-derived (e.g., murine) anti-RSV antibodies, the immunogenicity caused by specie differences is greatly reduced. With good specificity and affinity, if used for clinic, it will greatly reduce side effects.
(FR) L'invention concerne un anticorps (de préférence un anticorps complètement humanisé R66) contre le virus respiratoire syncytial RSV, les acides nucléiques codant pour ce dernier, un vecteur et une cellule hôte comprenant ces derniers, et une méthode de préparation de ces derniers. L'invention concerne également une utilisation de l'anticorps (de préférence un anticorps complètement humanisé R66) contre le RSV dans la prévention et le traitement de maladies liées au RSV, et une utilisation de ce dernier dans la détection du RSV. Cet anticorps contre le RSV est de préférence un anticorps monoclonal complètement humanisé. Par rapport aux autres anticorps anti-RSV d'origine animale (par exemple murins), l'immunogénicité liée à la différence d'espèce est fortement diminuée. Avec de bonnes spécificité et affinité, il permet de réduire considérablement les effets indésirables en cas d'une utilisation en clinique.
(ZH) 针对RSV的抗体(优选为全人源抗体R66)、其编码核酸、包含它的载体和宿主细胞以及它的制备方法。上述针对RSV的抗体(优选为全人源抗体R66)在预防和治疗RSV相关疾病中的应用,以及它们在检测RSV中的应用。上述针对RSV的抗体优选为是全人源的单克隆抗体,与其它动物源性(如鼠源性)的抗RSV抗体相比,因物种差异导致的免疫原性大大减少,且特异性好、亲和力高,如果用于临床将大大降低副作用。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
AU2016363455KR1020180089438EP3385278