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1. (WO2017092558) POLYPEPTIDE, LIPOPROTEIN-LIKE NANOPARTICLE AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/092558 International Application No.: PCT/CN2016/105330
Publication Date: 08.06.2017 International Filing Date: 10.11.2016
IPC:
C07K 19/00 (2006.01) ,A61K 47/42 (2017.01) ,A61K 47/24 (2006.01) ,A61K 9/51 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
中国科学院苏州纳米技术与纳米仿生研究所 SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS (SINANO), CHINESE ACADEMY OF SCIE [CN/CN]; 中国江苏省苏州市 苏州工业园区若水路398号 No. 398 Ruoshui Road, SIP Suzhou, Jiangsu 215123, CN
Inventors:
费浩 FEI, Hao; CN
王乔 WANG, Qiao; CN
马晓川 MA, Xiaochuan; CN
贾俊丽 JIA, Junli; CN
Agent:
南京利丰知识产权代理事务所(特殊普通合伙) NANJING LI&FENG INTELLECTUAL PROPERTY AGENCY (SPECIAL GENERAL PARTNERSHIP); 中国江苏省南京市 秦淮区中华路50号江苏国际经贸大厦1801室王锋 WANG Feng Room 1801, Jiangsu International Trade Building No. 50, Zhonghua Road, Qinhuai District Nanjing, Jiangsu 211100, CN
Priority Data:
201510881747.703.12.2015CN
Title (EN) POLYPEPTIDE, LIPOPROTEIN-LIKE NANOPARTICLE AND USE THEREOF
(FR) POLYPEPTIDE, NANOPARTICULE DE TYPE LIPOPROTÉINE ET UTILISATION CORRESPONDANTE
(ZH) 多肽、脂蛋白样纳米粒子及其应用
Abstract:
(EN) Disclosed are a polypeptide, a lipoprotein-like nanoparticle (LNP) and a use thereof. The LNP contains at least one phospholipid and at least one polypeptide. The polypeptide is the polypeptide with the structure of a helix-loop-helix, and comprises at least two amphipathic á-helixes. The two amphipathic á-helixes are connected through a connecting peptide comprising a cyclic structure.
(FR) La présente invention concerne un polypeptide, une nanoparticule de type lipoprotéine (NPL) et une utilisation correspondante. La NPL contient au moins un phospholipide et au moins un polypeptide. Le polypeptide est le polypeptide doté de la structure d'une hélice-boucle-hélice et comprend au moins deux α-hélices amphipathiques. Les deux hélices α-amphipathiques sont reliées via un peptide de liaison comprenant une structure cyclique.
(ZH) 本发明公开了一种多肽、脂蛋白样纳米粒子(LNP)及其应用。所述LNP包含至少一种磷脂和至少一种多肽。所述多肽为螺旋-环-螺旋结构多肽,其包含至少两个双亲性α螺旋,该两个双亲性α螺旋之间通过包含有环状结构的连接肽连接。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)