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1. (WO2017092483) KIT FOR DIAGNOSING TUBERCULOSIS THROUGH DETECTING FREE NUCLEIC ACID AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/092483 International Application No.: PCT/CN2016/099317
Publication Date: 08.06.2017 International Filing Date: 19.09.2016
IPC:
C12Q 1/68 (2006.01) ,C12Q 1/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Applicants:
首都医科大学附属北京胸科医院 BEIJING CHEST HOSPITAL, CAPITAL MEDICAL UNIVERSITY [CN/CN]; 中国北京市 通州区北关大街9号院 No.9 Yard, Beiguan Street, Tongzhou District Beijing 101149, CN
北京市结核病胸部肿瘤研究所 BEIJING TUBERCULOSIS AND THORACIC TUMOR RESEARCH INSTITUTE [CN/CN]; 中国北京市 通州区北关大街9号院北京胸科医院病理科 Department of Pathology, Beijing Chest Hospital, 9 BEIGUANDAJIE, Tongzhou District Beijing 101149, CN
Inventors:
车南颖 CHE, Nanying; CN
陈效友 CHEN, Xiaoyou; CN
杨新婷 YANG, Xinting; CN
张海青 ZHANG, Haiqing; CN
Agent:
北京超凡志成知识产权代理事务所 (普通合伙) CHOFN INTELLECTUAL PROPERTY; 中国北京市 海淀区北四环西路68号左岸工社1215-1218室 Room 1215-1218, Floor 12 Left Bank Community No. 68 Beisihuanxilu, Haidian District Beijing 100080, CN
Priority Data:
201510870799.402.12.2015CN
Title (EN) KIT FOR DIAGNOSING TUBERCULOSIS THROUGH DETECTING FREE NUCLEIC ACID AND USE THEREOF
(FR) KIT DE DIAGNOSTIC DE LA TUBERCULOSE PAR DÉTECTION D'ACIDE NUCLÉIQUE LIBRE ET UTILISATION ASSOCIÉE
(ZH) 通过检测游离核酸诊断结核病的试剂盒及其应用
Abstract:
(EN) Disclosed are a kit for diagnosing tuberculosis through detecting a free nucleic acid and a use thereof: in particular, the use of the substances used for detecting whether the free nucleic acid in body fluids contains mycobacterium tuberculosis specific genes in preparing a kit for diagnosing tuberculosis or assisting with a tuberculosis diagnosis, wherein the substances used for detecting whether the free nucleic acid in the body fluids contains the mycobacterium tuberculosis specific genes comprise: (1) a substance used for extracting the free nucleic acid from the body fluids; and (2) a substance used for detecting whether the free nucleic acid contains the mycobacterium tuberculosis specific genes. Tuberculosis is diagnosed by detecting the free nucleic acid, and since the free nucleic acid does not require the collecting of viable bacteria of mycobacterium tuberculosis or intact bacteria, compared with other nucleic acid detection methods, the kit has better safety and sensitivity. Meanwhile, the product can provide a result within 3 hours, and has the characteristics of being quick and convenient, etc.
(FR) L'invention concerne un kit de diagnostic de la tuberculose par détection d'un acide nucléique libre et son utilisation : en particulier, l'utilisation des substances servant à détecter si l'acide nucléique libre dans les liquides corporels contient ou non des gènes spécifiques de Mycobacterium tuberculosis dans la préparation d'un kit de diagnostic de la tuberculose ou d'aide au diagnostic de la tuberculose, les substances servant à détecter si l'acide nucléique libre dans les liquides corporels contient ou non les gènes spécifiques de Mycobacterium tuberculosis comprenant : (1) une substance utilisée pour extraire l'acide nucléique libre des liquides corporels; et (2) une substance utilisée pour détecter si l'acide nucléique libre contient ou non les gènes spécifiques de Mycobacterium tuberculosis. La tuberculose est diagnostiquée par détection de l'acide nucléique libre, et étant donné que l'acide nucléique libre ne nécessite pas la collecte de bactéries viables de Mycobacterium tuberculosis ou de bactéries intactes, comparé à d'autres procédés de détection d'acide nucléique, le kit présente une plus grande sécurité et une une plus grande sensibilité. Le produit peut fournir un résultat en 3 heures, et possède les caractéristiques d'être rapide et pratique, etc.
(ZH) 一种通过检测游离核酸诊断结核病的试剂盒及其应用,具体为用于检测体液的游离核酸中是否含有结核分枝杆菌特异基因的物质在制备诊断或辅助诊断结核病的试剂盒中的应用;其中所述用于检测体液的游离核酸中是否含有结核分枝杆菌特异基因的物质,包括:(1)从体液中提取游离核酸的物质;(2)检测游离核酸中是否含有结核分枝杆菌特异基因的物质。通过检测游离核酸诊断结核病,由于游离核酸不需要收集结核分枝杆菌活菌或完整菌体,因此相比其他的核酸检测方法具有更好的安全性和敏感性。同时该产品可以在3小时内给出结果,具有快速、简便等特点。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
IN201827023831