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1. (WO2017092413) DIAMINOPYRIMIDINE COMPOUNDS AND COMPOSITION COMPRISING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/092413 International Application No.: PCT/CN2016/096320
Publication Date: 08.06.2017 International Filing Date: 23.08.2016
IPC:
C07D 239/28 (2006.01) ,A61K 31/505 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
深圳市塔吉瑞生物医药有限公司 SHENZHEN TARGETRX, INC. [CN/CN]; 中国广东省深圳 南山区科技园中区科苑路15号科兴科学园A栋1单元301单位 Building A1-301 15 Keyuan Road, Nanshan District Shenzhen, Guangdong 518000, CN
Inventors:
王义汉 WANG, Yihan; CN
李焕银 LI, Huanyin; CN
Priority Data:
201510875506.102.12.2015CN
201610587472.022.07.2016CN
Title (EN) DIAMINOPYRIMIDINE COMPOUNDS AND COMPOSITION COMPRISING SAME
(FR) COMPOSÉS DIAMINOPYRIMIDINE ET COMPOSITION COMPRENANT CEUX-CI
(ZH) 一种二氨基嘧啶化合物及包含该化合物的组合物
Abstract:
(EN) Provided are diaminopyrimidine compounds as shown in formula (I), and a pharmaceutical composition comprising the compounds or a crystal form, a pharmaceutically acceptable salt, a hydrate or solvate, a stereoisomer, a prodrug or an isotopic variant thereof. The diaminopyrimidine compounds and the composition comprising the compounds exhibit an excellent inhibitory effect against protein kinases. They also have better pharmacokinetic parameter characteristics, which allows increasing drug concentration of the compounds in an animal body and enhances drug efficacy and safety.
(FR) La présente invention concerne des composés diaminopyrimidine tels que présentés dans la formule (I), et une composition pharmaceutique comprenant lesdits composés ou une forme cristalline, un sel pharmaceutiquement acceptable, un hydrate ou un solvate, un stéréo-isomère, un promédicament ou une variante isotopique de ceux-ci. Les composés diaminopyrimidine et la composition comprenant lesdits composés présentent un excellent effet inhibiteur contre les protéines kinases. Ils présentent également de meilleures caractéristiques de paramètres pharmacocinétiques, ce qui permet d'augmenter la concentration en médicament des composés dans le corps d'un animal et d'améliorer l'efficacité et la sécurité des médicaments.
(ZH) 一种如式(I)所示的二氨基嘧啶化合物及包含该化合物或其晶型、药学上可接受的盐、水合物或溶剂合物、立体异构体、前药或同位素变体的药物组合物。所述的二氨基嘧啶化合物及包含该化合物的组合物对蛋白激酶具有优异的抑制性,同时具有更好的药代动力学参数特性,能够提高化合物在动物体内的药物浓度,以提高药物疗效和安全性。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)